Parametric Imaging With PET and SPECT
Parametric Imaging With PET and SPECT
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DOI：
10.1109/trpms.2019.2908633
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发表时间：
2020-01-01
影响因子：
4.4
通讯作者：
Carson, Richard E.
中科院分区：
文献类型：
--
作者：
Gallezot, Jean-Dominique;Lu, Yihuan;Carson, Richard E.
在正电子发射断层扫描(PET)或单光子发射计算机断层扫描(SPECT)等分子成像方式中，参数成像是从一系列动态的放射性示踪剂浓度图像中创建完全定量的三维药代动力学参数图的过程。概述了在PET或SPECT研究中已评估的药代动力学参数，以及已提出的用于计算参数图像的动力学模型。由于从扫描仪获得的原始图像中的高水平噪声，以及在通常较长的动态扫描期间需要获得动力学模型的输入函数和校正对象运动，参数成像是具有挑战性的。对提出的评估这些挑战的方法进行了审查。
TIn molecular imaging modalities such as positron emission tomography (PET) or single photon emission computed tomography (SPECT), parametric imaging is the process of creating fully quantitative 3-D maps of pharmacokinetic parameters from a dynamic series of radiotracer concentration images. An overview of the pharmacokinetic parameters that have been assessed in PET or SPECT studies, and the kinetic models that have been proposed to compute parametric images is presented. Parametric imaging is challenging due to the high level of noise in the raw images obtained from the scanner, and the additional needs to obtain the input function of the kinetic model and to correct for subject motion during the usually long dynamic scans. Methods that have been proposed to assess each of these challenges are been reviewed.