Using constraints and their value for optimization of large ODE systems.
Using constraints and their value for optimization of large ODE systems.
复制标题
使用约束及其价值来优化大型 ODE 系统。
DOI：
10.1098/rsif.2014.1303
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Domijan M
中科院分区：
文献类型：
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作者：
Domijan M
我们提供分析工具，以促进对复杂模型与数据拟合的质量和价值进行严格评估。我们用它来提供方法，模型拟合，参数估计，优化功能的设计和实验优化。这是在使用多个约束来选择或优化由微分方程定义的大型模型的情况下。我们使用生物钟模型和NF-κB信号系统来说明这种方法。
We provide analytical tools to facilitate a rigorous assessment of the quality and value of the fit of a complex model to data. We use this to provide approaches to model fitting, parameter estimation, the design of optimization functions and experimental optimization. This is in the context where multiple constraints are used to select or optimize a large model defined by differential equations. We illustrate the approach using models of circadian clocks and the NF-κB signalling system.