Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia
Acetylenic acids inhibiting azole-resistant Candida albicans from Pentagonia gigantifolia
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DOI：
10.1021/np030196r
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发表时间：
2003-08-01
影响因子：
5.1
通讯作者：
Clark, AM
中科院分区：
文献类型：
--
作者：
Li, XC;Jacob, MR;Clark, AM
在抗真菌生物测定的指导下，从五倍子根的乙醇提取物中分离得到6-十八烷酸(1)和新的6-二十八烷酸(2)。化合物1和2对氟康唑敏感和耐药白念珠菌的生长均有抑制作用。其抗真菌活性与两性霉素B和氟康唑相当。具有特别重要意义的是1和2对白色念珠菌的低细胞毒性和比活性。
Antifungal bioassay-guided isolation of the ethanol extract of the roots of Pentagonia gigantifolia yielded 6-octadecynoic acid (1) and the new 6-nonadecynoic acid (2). Compounds 1 and 2 inhibited the growth of fluconazole-susceptible and -resistant Candida albicans strains. Their antifungal potencies were comparable to those of amphotericin B and fluconazole. Of particular significance is the low cytotoxicity and specific activity of 1 and 2 against C. albicans.