The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study
The Effects of Stimulator, Waveform, and Current Direction on Intracortical Inhibition and Facilitation: A TMS Comparison Study
复制标题
DOI：
10.3389/fnins.2019.00703
复制
发表时间：
2019-07
影响因子：
4.3
通讯作者：
M. Wessel;L. Draaisma;T. Morishita;F. Hummel
中科院分区：
文献类型：
--
作者：
M. Wessel;L. Draaisma;T. Morishita;F. Hummel
背景：皮质功能依赖于兴奋性和抑制性影响之间的平衡。在人类运动皮层中，这些相互作用的替代物可以在体内用双脉冲经颅磁刺激（TMS）非侵入性地测量。为了比较使用不同可用设置获取的数据的结果并将数据汇集在一起，不可避免地要确定不同的TMS设置是否会导致可比或差异的结果。目的：我们评估和比较短的皮质内抑制（SICI）和皮质内易化（ICF）测试四种不同的实验条件。研究方法：用不同的刺激物研究了SICI和ICF（Magstim BiStim 2或MagVenture MagPro X100），波形（单相或双相），电流方向（前-后或后-前）在1、3、10、15 ms的刺激间间隔（ISI）。当比较测试条件时，我们无法检测到SICI和ICF的差异，除了3 ms的SICI，其中前-后电流方向导致更强的调制。相关性分析表明，Magstim单相后-前条件下的3 ms SICI与两种受试MagVenture条件下的SICI具有可比性。结论：使用两种不同的常用刺激器（Magstim BiStim 2或MagVenture MagPro X100）和常规使用的刺激参数获得的3 ms SICI数据集在很大程度上具有可比性。这可以允许在开放科学视图中组合数据集。
Background: Cortical function is dependent on the balance between excitatory and inhibitory influences. In the human motor cortex, surrogates of these interactions can be measured in vivo, non-invasively with double-pulse transcranial magnetic stimulation (TMS). To compare results from data acquired with different available setups and bring data together, it is inevitable to determine whether different TMS setups lead to comparable or differential results. Objective: We assessed and compared short intracortical inhibition (SICI) and intracortical facilitation (ICF) testing four different experimental conditions. Methods: SICI and ICF were studied with different stimulators (Magstim BiStim2 or MagVenture MagPro X100), waveforms (monophasic or biphasic), current directions (anterior-posterior or posterior-anterior) at interstimulus intervals (ISIs) of 1, 3, 10, 15 ms. Results: We were not able to detect differences for SICI and ICF, when comparing the tested conditions, except for 3 ms SICI in which the anterior-posterior current direction led to stronger modulation. Correlation analysis suggested comparability for 3 ms SICI for the Magstim monophasic posterior-anterior condition with both tested MagVenture conditions. Conclusions: 3 ms SICI data sets obtained with two different, commonly used stimulators (Magstim BiStim2 or MagVenture MagPro X100) with conventionally used stimulation parameters are largely comparable. This may allow the combination of data sets in an open science view.