Moderate regular exercise increases basal production of nitric oxide in elderly women
Moderate regular exercise increases basal production of nitric oxide in elderly women
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DOI：
10.1291/hypres.27.947
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Matsuda, M
中科院分区：
文献类型：
--
作者：
Maeda, S;Tanabe, T;Matsuda, M
血管内皮细胞产生一氧化氮（NO），这是一种有效的血管扩张物质，被认为具有抗动脉粥样硬化特性。因此，也有人提出，NO可能是有用的，以调节血管紧张性和防止动脉粥样硬化的进展。另一方面，NO活性随着衰老而降低。我们以前报道过，血浆亚硝酸盐/硝酸盐（NOx：NO的稳定终产物）浓度显着增加激烈的有氧运动训练在健康的年轻人。我们假设生活方式的改变（例如，即使是轻微的有规律的运动训练）也可以增加先前久坐不动的老年人的NO产生。我们测量了血浆氮氧化物浓度之前和之后的轻度有氧运动训练方案（骑自行车在腿部测力计在80%的耐力阈值为30分钟，5天/周）为3个月的老年妇女。此外，我们评估了血浆浓度的环磷酸鸟苷（cGMP），第二信使的NO，在相同的样本。运动训练3个月后，个体反应阈显著提高。运动训练后安静时血压明显下降。结果表明，老年妇女3个月的运动训练产生了良好的生理效应。运动训练后血浆NOx浓度显著升高，cGMP浓度也显著升高。目前的研究表明，即使是温和的定期有氧耐力运动也会增加以前久坐不动的老年人的NO产生，这可能具有有益的效果（Le.，内源性NO对心血管系统的抗高血压和抗动脉粥样硬化作用。
Vascular endothelial cells produce nitric oxide (NO), which is a potent vasodilator substance and is thought to have antiatherosclerotic properties. Therefore, it has also been proposed that NO may be useful to regulate vascular tonus and prevent progression of atherosclerosis. On the other hand, NO activity reduces with aging. We previously reported that the plasma nitrite/nitrate (NOx: the stable end product of NO) concentration was significantly increased by intense aerobic exercise training in healthy young humans. We hypothesized that lifestyle modification (e.g., even mild regular exercise training) can increase NO production in previously sedentary older humans. We measured the plasma NOx concentration before and after a mild aerobic exercise training regimen (cycling on a leg ergometer at 80% ventilatory threshold for 30 min, 5 days/week) for 3 months in elderly women. In addition, we assessed the plasma concentration of cyclic guanosine monophosphate (cGMP), a second messenger of NO, in the same samples. The individual ventilatory threshold increased significantly after the 3-month exercise training. The blood pressure at rest significantly decreased after exercise training. These results suggest that the 3-month exercise training in the older women produced favorable physiological effects. The plasma concentration of NOx significantly increased by the exercise training, and the plasma concentration of cGMP also increased by the exercise training. The present study suggests that even a mild regular aerobic-endurance exercise increases NO production in previously sedentary older humans, which may have beneficial effects (Le., anti hypertensive and antiatherosclerotic effects by endogenous NO) on the cardiovascular system.