Anatomy and Development of the Nervous System of Nematostella vectensis, an Anthozoan Cnidarian
Anatomy and Development of the Nervous System of Nematostella vectensis, an Anthozoan Cnidarian
复制标题
DOI：
10.1002/dneu.20698
复制
发表时间：
2009-03-01
影响因子：
3
通讯作者：
Martindale, Mark Q.
中科院分区：
文献类型：
--
作者：
Marlow, Heather Q.;Srivastava, Mansi;Martindale, Mark Q.
Nematostella vectensis 是一种刺胞动物，其基因组已被测序，适合发育和生态研究，具有复杂的神经形态，在从幼虫到成虫的发育过程中发生了变化。 N. vectensis 的神经系统是一个弥漫性神经网络，具有外胚层感觉细胞和效应细胞以及内胚层多极神经节细胞。该神经网由沿着口-口轴的几个不同的神经区域组成，包括咽和口神经环以及幼虫顶端簇。这些神经化区域对应于保守两侧神经发育调节基因的表达，包括同源域转录因子和 NCAM。用 NvMsi、NvELAV 和 NvGCM 鉴定的早期神经元和干细胞群表明，神经分化发生在整个动物体内，并在原肠胚形成结束之前开始。 N. vectensis 的神经特化似乎是通过一种独立于经典刺胞动物模型水螅的机制发生的。 (C) 2009 年 Wiley 期刊。 Inc. 开发 Neurobiol 69: 235-254, 2009
Nematostella vectensis, an anthozoan cnidarian, whose genome has been sequenced and is suitable for developmental and ecological studies, has a complex neural morphology that is modified during development from the larval to adult form. N. vectensis' nervous system is a diffuse nerve net with both ectodermal sensory and effector cells and endodermal multipolar ganglion cells. This nerve net consists of several distinct neural territories along the oral-aboral axis including the pharyngeal and oral nerve rings, and the larval apical tuft. These neuralized regions correspond to expression of conserved bilaterian neural developmental regulatory genes including homeodomain transcription factors and NCAMs. Early neurons and stem cell populations identified with NvMsi, NvELAV, and NvGCM, indicate that neural differentiation occurs throughout the animal and initiates prior to the conclusion of gastrulation. Neural specification in N. vectensis appears to occur through an independent mechanism from that in the classical cnidarian model Hydra. (C) 2009 Wiley Periodicals. Inc. Develop Neurobiol 69: 235-254, 2009