Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study
Contribution of influenza and respiratory syncytial virus to community cases of influenza-like illness: an observational study
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DOI：
10.1016/s0140-6736(01)06528-x
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发表时间：
2001-10-27
期刊：
影响因子：
168.9
通讯作者：
Fleming, DM
中科院分区：
文献类型：
--
作者：
Zambon, MC;Stockton, JD;Fleming, DM
背景呼吸道合胞病毒(RSV)是引起儿童和老年人下呼吸道感染的重要原因之一，但其在其他年龄段的作用尚不清楚。我们在连续三个冬季(1995-96、1996-97和1997-98)对英国社区居民中患有流行性感冒类疾病的所有年龄段的居民进行了RSV感染的社区观察研究。方法采用多重逆转录聚合酶链式反应检测常规送检的鼻咽拭子中的甲型和乙型流感病毒以及甲型和乙型呼吸道合胞病毒，结果与当时流行性感冒样疾病和急性支气管炎的临床发病率有关。将鉴定出的RSV毒株与入院时获得的RSV毒株进行比较，在总共提交的2226份拭子中鉴定出480份RSV和709份流感病毒。这两种病毒在所有年龄组中都在每年冬天的12到20周内被发现。呼吸道合胞病毒A占检出RSV的60%。在同一年，医院和社区的病人中也出现了类似的RSV毒株，但每年都有不同的谱系。对被诊断为流行性感冒样疾病的个人来说，很可能会混淆由流感引起的疾病和由RSV引起的疾病。需要明确每一种疾病的负担，以确定最佳的管理程序。
Background Respiratory syncytial virus (RSV) is an important cause of lower-respiratory-tract infection in children and elderly people, but its effect in other age-groups is uncertain. We did a community-based observational study of RSV infection in community-dwelling individuals of all ages who presented to general practices in the UK with influenza-like illnesses during three successive winters (1995-96,1996-97, and 1997-98).Methods Nasopharyngeal swabs routinely submitted for virological surveillance were examined by multiplex reverse transcription PCR for influenza A and B viruses and, RSV A and B, and findings were related to the clinical incidence of influenza-like illness and acute bronchitis at that time. RSV strains identified were compared with those obtained from hospital admissions.Findings 480 RSV and 709 influenza viruses were identified from a total of 2226 swabs submitted. Both types of virus were found in all age-groups for between 12 and 20 weeks In each winter. RSV A accounted for 60% of RSV detections. Similar strains of RSV were present in hospital and community patients within the same year, but there were different lineages each year.Interpretation In individuals diagnosed with Influenza-like illness, there is a substantial potential for confusion between illnesses caused by influenza and those caused by RSV. The burden of illness attributable to each needs to be clarified to define optimum management routines.