Genetic lesions and targeted therapy in Hodgkin lymphoma.
Genetic lesions and targeted therapy in Hodgkin lymphoma.
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DOI：
10.1177/20406207221149245
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发表时间：
2023
影响因子：
3.4
通讯作者：
Xiao, Min
中科院分区：
文献类型：
--
作者：
Li, Zhe;Mu, Wei;Xiao, Min
关键词：
霍奇金淋巴瘤是一种特殊类型的淋巴瘤，其肿瘤细胞经常经历与伴随通路异常相关的多个基因损伤。这些通路的异常主要是由活跃的信号通路主导的，如JAK-STAT(Janus Kinase-Signal Transfer and Actifator of Transcription)通路和NF-κB(核因子kappaB)通路，它们通常导致生存信号的过度活跃。靶向治疗往往在血液系统恶性肿瘤中发挥重要作用，如针对CD19和CD22的CAR-T治疗(针对弥漫性大B细胞淋巴瘤)，而在霍奇金淋巴瘤，靶向治疗的主要靶点是CD30分子和PD1分子。针对其他分子的药物也在调查中。本文综述了霍奇金淋巴瘤的可操作基因损伤、目前的治疗选择、临床试验以及这些基因损伤在临床应用中的潜在价值。
Hodgkin lymphoma is a special type of lymphoma in which tumor cells frequently undergo multiple genetic lesions that are associated with accompanying pathway abnormalities. These pathway abnormalities are dominated by active signaling pathways, such as the JAK-STAT (Janus kinase–signal transducer and activator of transcription) pathway and the NFκB (nuclear factor kappa-B) pathway, which usually result in hyperactive survival signaling. Targeted therapies often play an important role in hematologic malignancies, such as CAR-T therapy (chimeric antigen receptor T-cell immunotherapy) targeting CD19 and CD22 in diffuse large B-cell lymphoma, while in Hodgkin lymphoma, the main targets of targeted therapies are CD30 molecules and PD1 molecules. Drugs targeting other molecules are also under investigation. This review summarizes the actionable genetic lesions, current treatment options, clinical trials for Hodgkin lymphoma and the potential value of those genetic lesions in clinical applications.
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