The Important Role and Implications of Citrate in the Composition, Structure, and Function of Oral/Periodontal/Craniofacial Tissues.
The Important Role and Implications of Citrate in the Composition, Structure, and Function of Oral/Periodontal/Craniofacial Tissues.
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DOI：
10.18689/mjdl-1000120
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发表时间：
2018-01-01
期刊：
影响因子：
--
通讯作者：
Reynolds, M A
中科院分区：
文献类型：
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作者：
Costello, L C;Franklin, R B;Reynolds, M A
高浓度的柠檬酸盐是人类和其他骨脊椎动物颅面骨、牙齿和牙周组织结构的主要成分。现在已经确定，柠檬酸盐掺入骨的磷灰石/胶原复合物对骨的重要生物力学特性的表现是必不可少的；比如稳定性、强度和抗断裂性。成骨细胞是专门的柠檬酸盐产生细胞，在成骨干细胞分化过程中提供纳入骨中的柠檬酸盐以产生新骨；与矿化同时发生的“柠檬酸化”。牙本质和牙骨质含有高水平的柠檬酸盐；与珐琅中的低柠檬酸盐形成对比。目前还没有关于在牙本质或牙骨质中掺入柠檬酸盐的状况和来源的信息。这些都是与口腔、牙周、颅面结构有关的重要问题。例如，缺陷的修复应该包括新组织，该组织表现出“正常”组织的组成、结构和生物力学特性；如果没有在新组织中掺入柠檬酸盐，这是无法实现的。不幸的是，在过去的40年里，牙科和医学界在这些组织中柠檬酸盐的存在和作用在很大程度上被忽视和忽视了。这篇综述的目的是重新建立对重要的柠檬酸关系和问题的兴趣和研究；专注于牙科相关的兴趣。
High citrate concentration is a major component in the structure of craniofacial bone, teeth and periodontal tissues of humans and other osteovertebrates. It is now established that citrate incorporation into the apatite/collagen complex of bone is essential for the manifestation of the important biomechanical properties of bone; such as stability, strength, and resistance to fracture. The osteoblasts are specialized citrate-producing cells that provide the citrate incorporated in bone during osteogenic stem cell differentiation for production of new bone; "citration" that occurs in concert with mineralization. Dentin and cementum contain high citrate levels; as contrasted with low citrate in enamel. There exists no information regarding the status and source of incorporated citrate in dentin or in cementum. These are important issues relating to oral, periodontal, craniofacial structures. For example, repair of defects should include new tissue that exhibits the composition, structure, and biomechanical properties of the "normal" tissue; which cannot be achieved in the absence of citrate incorporation in the new tissues. Unfortunately, the presence and role of citrate in these tissues have been largely ignored and unrecognized over the past about 40 years by the dental and medical community. The intent of this review is to re-establish the interest and research regarding the important citrate relationships and issues; with focus on related interests in dentistry.