Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF–EDG5 cascade
Genomic analysis of a mouse model of immunoglobulin A nephropathy reveals an enhanced PDGF–EDG5 cascade
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免疫球蛋白 A 肾病小鼠模型的基因组分析揭示了 PDGF-EDG5 级联增强
DOI：
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
G. Tsujimoto
中科院分区：
文献类型：
--
作者：
S. Katsuma;S. Shiojima;A. Hirasawa;Y. Suzuki;K. Takagaki;M. Murai;Y. Kaminishi;Y. Hada;M. Koba;E. Muso;S. Miyawaki;T. Ohgi;J. Yano;G. Tsujimoto
The molecular mechanism of immunoglobulin A nephropathy (IgAN), the most common primary renal glomerular disease worldwide, is unknown. HIGA (high serum IgA) mouse is a valid model of IgAN showing almost all of the pathological features, including mesangial cell proliferation. Here we elucidate a pattern of gene expression associated with IgAN by analyzing the diseased kidneys on cDNA microarrays. In particular, we showed an enhanced expression of several genes regulating the cell cycle and proliferation, including growth factors and their receptors, as well as endothelial differentiation gene-5 (EDG5), a receptor for sphingosine 1-phosphate (SPP). One of the growth factors, platelet-derived growth factor (PDGF) induces a marked upregulation of EDG5 in proliferative mesangial cells, and promotes cell proliferation synergistically with SPP. The genomic approach allows us to identify families of genes involved in a process, and can indicate that enhanced PDGF-EDG5 signaling plays an important role in the progression of IgAN.
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影响因子：
19.6
作者：
Shankland, SJ;Pippin, J;Johnson, RJ
通讯作者：
Johnson, RJ
影响因子：
20.3
作者：
Yutaka Yatomi;Fuqiang Ruan;S. Hakomori;Yasuyuki Igarashi
通讯作者：
Yutaka Yatomi;Fuqiang Ruan;S. Hakomori;Yasuyuki Igarashi
影响因子：
13.2
作者：
COUSER, WG;JOHNSON, RJ
通讯作者：
JOHNSON, RJ
溶血磷脂和溶血鞘脂的 G 蛋白偶联细胞受体亚家族。
影响因子：
--
作者：
Goetzl,EJ;An,S
通讯作者：
An,S
IgA 肾病：最常见形式的肾小球肾炎的发病机制。
DOI：
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发表时间：
1989
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Emancipator,SN;Lamm,ME
通讯作者：
Lamm,ME