A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management
A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management
复制标题
DOI：
10.1109/jssc.2014.2346779
复制
发表时间：
2014-10-01
影响因子：
5.4
通讯作者：
Flynn, Michael P.
中科院分区：
文献类型：
--
作者：
Rhew, Hyo-Gyuem;Jeong, Jaehun;Flynn, Michael P.
尽管闭环深部脑刺激 (DBS) 有望治疗许多神经系统疾病，但实现有效闭环 DBS 算法的植入式片上系统 (SoC) 尚未得到证实。这项工作介绍了一种对数闭环 DBS 系统，该系统可检测和处理低频脑场信号以控制和适应刺激电流。该系统通过四个低噪声神经放大器 (LNA) 通道、一个多路复用对数 ADC 以及两个高通和两个低通数字对数滤波器来记录和处理神经信号。对数处理可节省功耗并实现高动态范围。对数域数字信号处理器 (DSP) 和 PI 控制器控制八个电流刺激器通道并实现闭环刺激。系统中还包含射频收发器、时钟发生器和功率收集器，以实现完整的植入式 SoC。 4 mm(2) 180 nm CMOS 原型总共消耗 468 muW 用于记录和处理神经信号、刺激以及双向无线通信。
Although closed-loop deep brain stimulation (DBS) promises treatment of many neurological disorders, an implantable system-on-chip (SoC) implementing an effective closed-loop DBS algorithm has not been demonstrated. This work introduces a logarithmic, closed-loop DBS system that detects and processes low-frequency brain field signals to control and adapt stimulation currents. The system records and processes neural signals with four low-noise neural amplifier (LNA) channels, a multiplexed logarithmic ADC, and two high-pass and two low-pass digital logarithmic filters. Logarithmic processing saves power and achieves high dynamic range. A logarithmic domain digital signal processor (DSP) and PI-controller controls eight current stimulator channels and enables closed-loop stimulation. An RF transceiver, a clock generator, and a power harvester are also included in the system to achieve a complete implantable SoC. The 4 mm(2) 180 nm CMOS prototype consumes a total of 468 mu W for recording and processing neural signals, for stimulation, and for two-way wireless communication.