Computed fractional flow reserve (FFTCT) derived from coronary CT angiography.
Computed fractional flow reserve (FFTCT) derived from coronary CT angiography.
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DOI：
10.1007/s12265-013-9498-4
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发表时间：
2013-10
影响因子：
3.4
通讯作者：
Min, James K.
中科院分区：
文献类型：
--
作者：
Zarins, Christopher K.;Taylor, Charles A.;Min, James K.
关键词：
基于图像的建模和计算流体动力学的最新进展使通常获得的冠状动脉计算机断层扫描(CT)能够计算冠状动脉压力和流量。计算的血流储备分数是在模拟最大冠状动脉充血状态下平均冠状动脉压除以平均主动脉压的比率，从而提供冠状动脉树上每一点的血流储备分数(FFRCT)的无创性估计。前瞻性多中心临床试验表明，与以有创FFR为参考金标准相比，计算型FFRCT在诊断血流动力学意义重大的冠状动脉疾病(CAD)方面，与单纯CT狭窄相比，提高了诊断的准确性和区分性。这项前景看好的新技术在单一的非侵入性测试中提供了对CAD的综合解剖和生理评估，可以帮助选择患者进行有创血管造影术和血运重建或最佳药物治疗。对无创快速放射治疗的临床效果和经济影响的进一步评估目前正在探索中。
Recent advances in image-based modeling and computational fluid dynamics permit the calculation of coronary artery pressure and flow from typically acquired coronary computed tomography (CT) scans. Computed fractional flow reserve is the ratio of mean coronary artery pressure divided by mean aortic pressure under conditions of simulated maximal coronary hyperemia, thus providing a noninvasive estimate of fractional flow reserve (FFRCT) at every point in the coronary tree. Prospective multicenter clinical trials have shown that computed FFRCT improves diagnostic accuracy and discrimination compared to CT stenosis alone for the diagnosis of hemodynamically significant coronary artery disease (CAD), when compared to invasive FFR as the reference gold standard. This promising new technology provides a combined anatomic and physiologic assessment of CAD in a single noninvasive test that can help select patients for invasive angiography and revascularization or best medical therapy. Further evaluation of the clinical effectiveness and economic implications of noninvasive FFRCT are now being explored.
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影响因子：
37.8
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