Re-emergence of dengue virus serotype 3 infections in Gabon in 2016-2017, and evidence for the risk of repeated dengue virus infections
Re-emergence of dengue virus serotype 3 infections in Gabon in 2016-2017, and evidence for the risk of repeated dengue virus infections
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DOI：
10.1016/j.ijid.2019.12.002
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发表时间：
2020-02-01
影响因子：
8.4
通讯作者：
Yasuda, Jiro
中科院分区：
文献类型：
--
作者：
Abe, Haruka;Ushijima, Yuri;Yasuda, Jiro
目的：2007年和2010年在中非加蓬发生了主要由登革病毒血清型2（DENV-2）引起的登革热疫情。然而，自2010年以来，有关登革病毒感染的信息一直不足。本研究的目的是调查目前的DENV感染情况和重复感染的风险在Gabon.Methods：在2015-2017年期间，从登记的发热参与者中收集血清样本，并使用RT-qPCR检测DENV感染。使用ELISA分析DENV阳性样品的先前DENV感染史。结果：DENV-3仅检出DENV-3，DENV-3阳性人群中抗DENV IgG抗体阳性率较高。DENV-3在成人中的感染率较高，感染具有季节性，雨季为感染高峰。系统发育分析显示，加蓬DENV-3起源于西非菌株，并已连续在加蓬流通，因为至少2010年，当第一个DENV-3病例被报道。结论：这些研究结果表明，稳定的DENV-3循环和重复DENV感染的风险，在加蓬，强调需要持续监测，以控制DENV感染。(c)2019作者由Elsevier Ltd代表国际传染病学会出版。这是一个在CC BY-NC-ND许可证下的开放获取文章（http：//creativecommons.org/licenses/by-nc-nd/4.0/）。
Objectives: Dengue outbreaks, mainly caused by dengue virus serotype 2 (DENV-2), occurred in 2007 and in 2010 in Gabon, Central Africa. However, information on DENV infections has been insufficient since 2010. The aim of this study was to investigate the current DENV infection scenario and the risk of repeated infections in Gabon.Methods: During 2015-2017, serum samples were collected from enrolled febrile participants and were tested for DENV infection using RT-qPCR. DENV-positive samples were analyzed for a history of previous DENV infection(s) using ELISA. The complete DENV genome was sequenced to analyze the phylogeny of Gabonese DENV strains.Results: DENV-3 was exclusively detected, with a high rate of anti-DENV IgG seropositivity among DENV-3-positive participants. DENV-3 showed higher infection rates in adults and the infection was seasonal with peaks in the rainy seasons. Phylogenetic analysis revealed that Gabonese DENV-3 originated from West African strains and has been circulating continuously in Gabon since at least 2010, when the first DENV-3 case was reported.Conclusions: These findings indicate stable DENV-3 circulation and the risk of repeated DENV infections in Gabon, highlighting the need for continuous monitoring to control DENV infections. (c) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).