Controlled generation of monodisperse discoid droplets using microchannel arrays
Controlled generation of monodisperse discoid droplets using microchannel arrays
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DOI：
10.1021/la0623329
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发表时间：
2006-12-19
期刊：
影响因子：
3.9
通讯作者：
Nakajima, Mitsutoshi
中科院分区：
文献类型：
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作者：
Kobayashi, Isao;Uemura, Kunihiko;Nakajima, Mitsutoshi
我们报道了一种利用微通道（MC）阵列和浅井组成的独特微观结构产生几何限制液滴的新技术。硅MC阵列装置通过迫使待分散相通过通道进入充满连续相的井中，成功地生成了单分散的水包油（O/W）和W/O类型的盘状液滴。通过控制通道和井的尺寸，可以获得尺寸小至几微米的单分散盘状液滴。由此产生的盘状液滴在井中形成了一个几乎紧密排列的阵列。由硅油/水/十二烷基硫酸钠体系组成的单分散盘状液滴在7天的储存时间内没有聚结。此外，具有许多通道的MC阵列板可用于提高单个微流控装置的液滴生产率。
We report a novel technique for generating geometrically confined droplets using a unique microstructure composed of a microchannel (MC) array and a shallow well. Silicon MC array devices were successfully used to generate monodisperse discoid droplets of oil-in-water (O/W) and W/O types by forcing a to-be-dispersed phase through channels into a well filled with a continuous phase. Monodisperse discoid droplets with sizes down to several micrometers were obtained by controlling the channel and well dimensions. The resultant discoid droplets formed a mostly close-packed array in the well. Monodisperse discoid droplets consisting of a silicone oil/water/sodium dodecyl sulfate system did not coalesce during the storage time of seven days. Additionally, MC array plates with many channels can be useful for increasing the droplet productivity of a single microfluidic device.