Hydrocarbon exposure and chronic renal disease.
Hydrocarbon exposure and chronic renal disease.
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碳氢化合物暴露和慢性肾脏疾病。
DOI：
10.1007/bf00381433
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发表时间：
1996
影响因子：
3
通讯作者：
Kingsley,B
中科院分区：
文献类型：
--
作者：
Asal,NR;Cleveland,HL;Kaufman,C;Nsa,W;Nelson,DI;Nelson,RY;Lee,ET;Kingsley,B
这项研究的目的是通过更精确的碳氢化合物暴露测量，进一步调查长期接触碳氢化合物(HCS)在特发性慢性肾小球疾病(ICG)发展中的潜在作用。总共收集了321对病例和对照，按年龄、性别和地理区域匹配。向病例和对照盲目发放详细的问卷，以收集有关职业和病史以及社会人口学数据的信息。通过将来自不同来源的HC暴露的量化测量与每个受试者的职业史相结合，可以估计终生HC暴露分数并以百万分之(Ppm)表示。病例的碳氢化合物暴露平均得分为165ppm(中位数48ppm)，而对照组为162ppm(中位数43ppm)(P=0.757)。当使用碳氢化合物暴露作为一个二分变量，截止点为100ppm时，病例暴露于碳氢化合物的比例高于对照组，但差异在0.05水平上没有统计学意义，即使在通过Logistic回归控制了可能的混杂因素后也是如此。亚组分析显示结果喜忧参半。在大多数亚组中，当碳氢化合物被用作二分变量时，病例和对照之间的差异往往变得显着。这项研究的结果总体上不能充分支持HC暴露与ICG之间的假设联系。亚组分析需要进一步调查。在今后的研究中，应强调对终生碳氢化合物暴露的准确估计的努力。
The study objective was to investigate further the potential role of long-term exposure to hydrocarbons (HCs) in the development of idiopathic chronic glomerulopathy (ICG) using a more refined measurement of HC exposure. A total of 321 pairs of cases and controls, matched by age, gender, and geographical area, were assembled. A detailed questionnaire was blindly administered to cases and controls to collect information on occupational and medical history and sociodemographic data. By integrating quantified measurements of HC exposure from a variety of sources with each subject's occupational history, a lifetime HC exposure score could be estimated and expressed in parts per million (ppm). Cases had an hydrocarbon exposure mean score of 165 ppm (median 48 ppm) as compared to 162 ppm (median 43 ppm) for controls (P= 0.757). When using hydrocarbon exposure as a dichotomous variable with a cutoff point at 100 ppm, cases had a higher proportion of exposed than controls, but the difference was not statistically significant at the 0.05 level, even after controlling for possible confounders through logistic regression. Subgroup analyses showed mixed results. In most subgroups differences between cases and controls tended to become significant when hydrocarbon was used as a dichotomous variable. Results from this study do not sufficiently support the hypothesized association of HC exposure and ICG in general. Subgroup analyses need further investigations. Efforts to generate accurate estimates of lifetime HC exposure should be emphasized for future investigations.