Coenzyme Q, vitamin E and apo-E alleles in Alzheimer disease
Coenzyme Q, vitamin E and apo-E alleles in Alzheimer disease
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DOI：
10.1002/biof.5520180231
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发表时间：
2003-01-01
期刊：
影响因子：
6
通讯作者：
Villa, RF
中科院分区：
文献类型：
--
作者：
Battino, M;Bompadre, S;Villa, RF
神经退行性疾病是痴呆症的最常见原因，约占 65 岁以上人口的 5-10%，约 30% 超过 80 岁。一项以 Apo-E 等位基因、辅酶 Q 和维生素 E 作为生物指标的研究，对 30 至 85 岁神经退行性疾病患者的血浆样本进行了研究。将结果与与参考组年龄大致相同的对照受试者进行比较。估计对照组中 epsilon4 等位基因的频率为 21.7%，而在患者中观察到的频率为 15.8%。对照组中 epsilon2 和 epsilon3 等位基因的频率分别为 13.0% 和 65.2%，而患者中分别为 10.5% 和 73.7%。与患者组相比，对照组的epsilon3/epsilon3基因型和epsilon3/epsilon4基因型频率没有观察到显着差异。观察到的频率，epsilon2/epsilon3 基因型组为 8.7% vs 15.8%，e2/e4 基因型组为 17.4% vs 5.3%。在任何组中均未鉴定出 epsilon2/epsilon2 和 epsilon4/epsilon4 基因型。患者组和对照组的血浆 CoQ(10) 浓度相似，即使考虑到两组中男性和女性受试者的分布，也没有发现差异。此外，维生素 E 没有提供组间任何差异的证据，并且性别之间的分析再次表明，亚组之间的维生素 E 浓度相似。
Neurodegenerative Diseases represent the most commmon cause of Dementia, about 5-10% of the population aged above 65 years and about 30% above 80 years. A study about Apo-E alleles, Coenzyme Q and Vitamins E as biological indicators was performed in plasma samples of patients aged from 30 to 85 years, affected by Neurodegenerative Diseases. The results were compared with control subjects of approximately the same ages as the reference group.A frequency of 21.7% of epsilon4 allele in control group was estimated, against 15.8% observed in patients. The frequency of epsilon2 and epsilon3 alleles was 13.0% and 65.2% in the control group against 10.5% and 73.7% in patients. No significant differences were observed between the frequency of epsilon3/epsilon3 genotype and epsilon3/epsilon4 genotype in the control group compared to patients' group. The frequencies observed, in epsilon2/epsilon3 genotype groups were 8.7% vs 15.8% and of e2/e4 genotype 17.4% vs 5.3%. The epsilon2/epsilon2 and epsilon4/epsilon4 genotypes were not identified in any groups.Plasma CoQ(10) concentrations were similar in patient and control groups and no differences were found even taking into account the distribution of male and female subjects in the two groups. Also, vitamin E did not provide evidence of any differences between groups and the analysis among sexes revealed that again vitamin E concentrations were similar in between subgroups.