Bio-Inspired Self-Hydrophobized Sericin Adhesive with Tough Underwater Adhesion Enables Wound Healing and Fluid Leakage Sealing
Bio-Inspired Self-Hydrophobized Sericin Adhesive with Tough Underwater Adhesion Enables Wound Healing and Fluid Leakage Sealing
复制标题
DOI：
10.1002/adfm.202201108
复制
发表时间：
2022-05-17
影响因子：
19
通讯作者：
Wang, Lin
中科院分区：
文献类型：
--
作者：
Liu, Huan;Qin, Sumei;Wang, Lin
由于水的抗粘附性严重削弱了组织粘合剂的结合强度，因此在潮湿的生物组织表面上的即时粘附仍然是一个挑战。受天然生物强大的水下附着力的启发（如贻贝和藤瓶，其水下附着力来自疏水性和粘合基质的协同作用），将二硫键水解的疏水性天然丝胶蛋白（蚕丝纤维的主要成分）与单宁酸共组装而成一种自疏水性粘合剂。一旦暴露在水中，胶粘剂内部疏水链的自聚集就会排斥水，并增强界面氢键或静电相互作用，从而在机械上导致牢固（固体板>0.5 MPa，组织>0.1 MPa）和持久（即使在5个循环后仍保持在0.4 MPa）的水下粘附。由于其强大的水下粘附性能，该粘合剂具有比商用粘合剂更多的优点，如促进体内伤口愈合的效果，有效的液体泄漏密封，快速止血活性。本研究不仅为天然蛋白水下黏合剂的设计和制造提供了一种新的策略，而且为促进伤口愈合和止血等多种潜在应用提供了新的途径。
Given that adhesion-resistance of water severely weakens the bonding strength of tissue adhesives, instant adhesion to wet biological tissue surfaces remains challenging. Inspired by the robust underwater adhesion of natural creatures (such as mussels and barnacles whose underwater adhesion derives from the synergy of hydrophobic and adhesive matrix), a self-hydrophobized adhesive is developed by co-assembly of disulfide-bond hydrolyzed hydrophobic natural sericin protein (a major component of silkworm silk fibers) and tannic acid. Once exposed to water, the self-aggregation of hydrophobic chains within the adhesive repels water and enhances interfacial hydrogen bonding or electrostatic interactions, mechanistically leading to a robust (>0.5 MPa for solid plates and >0.1 MPa for tissues) and durable (still maintained at 0.4 Mpa even after five cycles) underwater adhesion. Owing to its robust underwater adhesion property, this adhesive possesses multiple advantages outperforming commercial adhesives, such as in vivo wound healing-promoting effects, effective fluid leakage sealing, and rapid hemostasis activity. This study not only offers a novel strategy for designing and fabricating an underwater adhesive with natural protein but also provides a new adhesive for various potential applications, including promoting wound healing and hemostasis.