Effects of exposure to ozone on defensive mechanisms of the lung.
Effects of exposure to ozone on defensive mechanisms of the lung.
复制标题
暴露于臭氧对肺部防御机制的影响。
DOI：
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发表时间：
1971
影响因子：
3.3
通讯作者：
D. Coffin
中科院分区：
文献类型：
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作者：
S. Alpert;D. Gardner;D. Hurst;T. Lewis;D. Coffin
单侧肺暴露于污染物可以区分原发性和稳态效应。将家兔单侧暴露于0.5、0.75或3 ppM O/sub ~ 3/中3小时，检测灌洗获得的肺泡巨噬细胞（PAM）。观察到来自暴露肺的PAM活力的剂量相关性降低。尽管PAM的绝对数量没有变化，但以PAM为代价的多形核白细胞增加。水解酶、酸性磷酸酶、溶菌酶和β-葡萄糖醛酸苷酶的活性呈剂量相关性降低，这些酶在消化吞噬的有机颗粒和微生物中至关重要。无可否认，在单侧暴露期间，更多的O/sub 3/将到达肺（较少的上呼吸道降解）。
Unilateral lung exposure to pollutants allows distinction between primary and homeostatic effects. Rabbits were exposed to 0.5, 0.75, or 3 ppM O/sub 3/ unilaterally for 3 hr. Pulmonary alveolar macrophages (PAM) obtained by lavage were tested. Dose-related decrease in PAM viability from exposed lung was observed. There was an increase in polymorphonuclear leukocytes at expense of PAM although absolute numbers of PAM did not change. There was a dose-related decrease in activity of hydrolytic enzymes, acid phosphatase, lysozyme, and beta-glucuronidase, critical in digestion of phagocytized organic particles and organisms. Admittedly more O/sub 3/ would reach lung during unilateral exposure (less upper airway degradation).