Effect of sex on Coxiella burnetii infection:: Protective role of 17β-estradiol
Effect of sex on Coxiella burnetii infection:: Protective role of 17β-estradiol
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DOI：
10.1086/380798
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发表时间：
2004-01-15
影响因子：
6.4
通讯作者：
Mege, JL
中科院分区：
文献类型：
--
作者：
Leone, M;Honstettre, A;Mege, JL
Q热是由贝氏柯克斯体引起的一种人畜共患病，最近被认为是一种潜在的生物恐怖主义因子。在Q热中，尽管血清阳性率相同，但男性比女性更容易出现症状。我们推测性激素在C.贝氏体感染C57/BL 6小鼠注射C.贝氏体、细菌负荷和肉芽肿数量在雌性中低于雄性。卵巢切除小鼠脾脏和肝脏中的细菌负荷增加，与雄性小鼠相似。卵巢切除小鼠的肉芽肿数量也增加，并达到雄性动物的水平。组织感染和肉芽肿反应在很大程度上受雌激素的控制：用17 β-雌二醇治疗卵巢切除的小鼠可减少细菌负荷和肉芽肿数量。这些结果表明，性激素控制寄主对C.贝氏体感染，并可能解释Q热的宿主依赖性临床表现。
Q fever is a zoonosis caused by Coxiella burnetii and recently has been recognized as a potential agent of bioterrorism. In Q fever, men are symptomatic more often than women, despite equal seroprevalence. We hypothesized that sex hormones play a role in the pathogenesis of C. burnetii infection. When C57/BL6 mice were injected with C. burnetii, bacteria load and granuloma numbers were lower in females than in males. Ovarectomized mice showed increased bacteria load in the spleen and the liver, similar to that found in males. The granuloma number was also increased in ovarectomized mice and reached the levels found in males. Tissue infection and granulomatous response are largely under the control of estrogens: treatment of ovarectomized mice with 17beta-estradiol reduced both bacteria loads and granuloma numbers. These results show that sex hormones control host response to C. burnetii infection and may account for host-dependent clinical presentation of Q fever.