A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations
A period of transient viremia and occult infection precedes persistent viremia and antiviral immune responses during multiple low-dose intravaginal simian immunodeficiency virus inoculations
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DOI：
10.1128/jvi.78.24.14048-14052.2004
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发表时间：
2004-12-01
影响因子：
5.4
通讯作者：
Miller, CJ
中科院分区：
文献类型：
--
作者：
Ma, ZM;Abel, K;Miller, CJ
在恒河猴中，多次低剂量(10(3)50%组织培养感染量)经阴道接种SIV株SIVmac251后，会发生典型的全身性感染，以持续性病毒血症和血清转换为特征。猴子在低剂量IVAG暴露于SIVmac251后出现典型的SIV感染。一旦确诊，全身感染与大剂量IVAG SIV接种后的SIV感染相同。然而，以一过性细胞相关性或无细胞病毒血症为特征的隐匿性全身性感染在多次阴道SIV暴露的一系列病例中持续发生。此外，在低剂量SIV阴道传播模型中，在建立典型的全身感染之前，存在抗病毒细胞免疫反应。
In rhesus macaques, classic systemic infection, characterized by persistent viremia and seroconversion, occurred after multiple low-dose (10(3) 50% tissue culture infective doses) intravaginal (IVAG) inoculations with simian immunodeficiency virus (SIV) strain SIVmac251. Monkeys developed classic SIV infections after a variable number of low-dose IVAG exposures to SIVmac251. Once established, the systemic infection was identical to SIV infection following high-dose IVAG SIV inoculation. However, occult systemic infection characterized by transient cell-associated or cell-free viremia consistently occurred early in the series of multiple vaginal SIV exposures. Further, antiviral cellular immune responses were present prior to the establishment of a classic systemic infection in the low-dose vaginal SIV transmission model.