Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
Peptidomics and processing of regulatory peptides in the fruit fly Drosophila
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DOI：
10.1016/j.euprot.2014.02.007
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发表时间：
2014-06
影响因子：
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通讯作者：
D. Pauls;Jiangtian Chen;W. Reiher;J. Vanselow;A. Schlosser;J. Kahnt;C. Wegener
中科院分区：
文献类型：
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作者：
D. Pauls;Jiangtian Chen;W. Reiher;J. Vanselow;A. Schlosser;J. Kahnt;C. Wegener
自果蝇黑胃基因组的发布和果蝇调节肽（神经肽和肽激素）的首次预测以来，已经过去了十多年。从那时起，基于质谱的方法推动了调节肽的化学特征，从基因组前区域的7种果蝇肽到今天的60多种。我们回顾了果蝇肽组学的发展，并提出了一个全面的清单，调控肽的化学特征，直到今天。我们还总结了果蝇的肽加工知识，这得益于基于质谱的技术和果蝇可用的遗传工具的结合。这种组合在研究多肽信号传导在各个水平上的功能生物学方面具有很高的潜力，特别是随着果蝇定量质谱的不断发展。
More than a decade has passed since the release of theDrosophila melanogastergenome and the first predictions of fruit fly regulatory peptides (neuropeptides and peptide hormones). Since then, mass spectrometry-based methods have fuelled the chemical characterisation of regulatory peptides, from 7Drosophilapeptides in the pre-genomic area to more than 60 today. We review the development of fruit fly peptidomics, and present a comprehensive list of the regulatory peptides that have been chemically characterised until today. We also summarise the knowledge on peptide processing inDrosophila, which has strongly profited from a combination of MS-based techniques and the genetic tools available for the fruit fly. This combination has a very high potential to study the functional biology of peptide signalling on all levels, especially with the ongoing developments in quantitative MS inDrosophila.