Fructus Xanthii attenuates hepatic steatosis in rats fed on high-fat diet.
Fructus Xanthii attenuates hepatic steatosis in rats fed on high-fat diet.
复制标题
苍耳子减轻高脂饮食大鼠的肝脏脂肪变性
DOI：
10.1371/journal.pone.0061499
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Li X
中科院分区：
文献类型：
--
作者：
Li X;Li Z;Xue M;Ou Z;Liu M;Yang M;Liu S;Yang S;Li X
苍耳子(FX)是治疗鼻炎、头痛、感冒等的传统中草药。现代药理研究表明，苍耳子具有抗炎、抗氧化、降血糖等作用。本研究旨在探讨FX对高脂饮食(HFD)大鼠血糖、胰岛素耐量及肝脂代谢的影响。高脂饲料喂养可引起大鼠肝脏脂肪变性。FX水提物或赋形剂水提物灌胃给药6周。监测体重和血糖。进行血糖和胰岛素耐量试验。苏木精-伊红染色和油红O染色观察肝脏形态。实时荧光定量聚合酶链式反应(Real-Time-PCR)检测肝脏生脂和解脂基因的表达。我们在这里表明，FX改善了HFD大鼠的糖耐量和胰岛素敏感性。FX能显著降低造脂基因的表达，增加脂解基因的表达，改善脂肪堆积，降低肝脏总甘油三酯(TG)含量，从而减轻HFD诱导的肝脏脂肪变性。综上所述，FX改善了HFD大鼠的糖耐量和胰岛素敏感性，减少了脂肪生成，增加了肝脏的脂质氧化，提示FX在治疗非酒精性脂肪性肝病方面具有潜在的应用价值。
Fructus Xanthii (FX) has been widely used as a traditional herbal medicine for rhinitis, headache, cold, etc. Modern pharmacological studies revealed that FX possesses anti-inflammatory, anti-oxidative, and anti-hyperglycemic properties. The present study was designed to investigate the effects of FX on glucose and insulin tolerance, and hepatic lipid metabolism in rats fed on high-fat diet (HFD). Hepatic steatosis was induced by HFD feeding. Aqueous extraction fractions of FX or vehicle were orally administered by gavage for 6 weeks. Body weight and blood glucose were monitored. Glucose and insulin tolerance test were performed. Liver morphology was visualized by hematoxylin and eosin, and oil red O staining. Expression of liver lipogenic and lipolytic genes was measured by real-time PCR. We showed here that FX improved glucose tolerance and insulin sensitivity in HFD rats. FX significantly decreased the expression of lipogenic genes and increased the expression of lipolytic genes, ameliorated lipid accumulation and decreased the total liver triglyceride (TG) content, and thus attenuated HFD-induced hepatic steatosis. In conclusion, FX improves glucose tolerance and insulin sensitivity, decreases lipogenesis and increases lipid oxidation in the liver of HFD rats, implying a potential application in the treatment of non-alcoholic fatty liver disease.
登录
查看更多内容
影响因子：
4.8
作者：
Cha, Ji-Young;Repa, Joyce J.
通讯作者：
Repa, Joyce J.
影响因子：
13.5
作者：
Stienstra, Rinke;Saudale, Fredy;Mueller, Michael
通讯作者：
Mueller, Michael
影响因子：
15.9
作者：
Shimano, H;Horton, JD;Goldstein, JL
通讯作者：
Goldstein, JL
影响因子：
7.7
作者：
Dentin, Renaud;Benhamed, Fadila;Postic, Catherine
通讯作者：
Postic, Catherine
影响因子：
20.3
作者：
BERGMAN, RN;FINEGOOD, DT;ADER, M
通讯作者：
ADER, M