Opinion - Bias as a threat to the validity of cancer molecular-marker research
Opinion - Bias as a threat to the validity of cancer molecular-marker research
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DOI：
10.1038/nrc1550
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发表时间：
2005-02-01
影响因子：
78.5
通讯作者：
Ransohoff, DF
中科院分区：
文献类型：
--
作者：
Ransohoff, DF
分子标记可以准确诊断癌症的说法最近受到了争议;一些突出的结果没有被复制，并且已经提出了解释原始观察结果的偏见。随着新的“组学”领域的探索，以评估癌症的分子标志物，偏见将越来越多地被认为是最重要的“有效性威胁”，必须在设计，进行和解释这样的研究。
Claims that molecular markers can accurately diagnose cancer have recently been disputed; some prominent results have not been reproduced and bias has been proposed to explain the original observations. As new '-omics' fields are explored to assess molecular markers for cancer, bias will increasingly be recognized as the most important 'threat to validity' that must be addressed in the design, conduct and interpretation of such research.