Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings.
Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings.
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DOI：
10.3233/jad-220885
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Marshall GA
中科院分区：
文献类型：
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作者：
Gonzalez C;Mimmack KJ;Amariglio RE;Becker JA;Chhatwal JP;Fitzpatrick CD;Gatchel JR;Johnson KA;Katz ZS;Kuppe MK;Locascio JJ;Udeogu OJ;Papp KV;Premnath P;Properzi MJ;Rentz DM;Schultz AP;Sperling RA;Vannini P;Wang S;Marshall GA
在阿尔茨海默病（AD）的早期阶段检测日常生活工具活动（IADL）的临床意义变化是至关重要的。本探索性研究的目的是检查基于性能的IADL测试、哈佛自动电话任务（APT）与认知正常（CN）老年人大脑tau和淀粉样蛋白负担之间的横断关系。77名CN参与者接受了flortaucipir tau和匹兹堡化合物B淀粉样蛋白PET。IADL使用三个哈佛APT任务进行评估：处方补充（APT- script）、健康保险公司电话（APT- pcp）和银行交易（APT- bank）。线性回归模型用于确定每个APT任务与内嗅皮层、下颞叶或楔前叶tau是否与淀粉样蛋白相互作用之间的关系。APT-Bank任务率与淀粉样蛋白与内鼻皮层tau相互作用、APT-PCP任务率与淀粉样蛋白与下颞叶和额前叶tau相互作用存在显著相关性。APT任务与单独的tau或淀粉样蛋白之间没有明显的关联。我们的初步研究结果表明，模拟现实生活中的IADL测试与CN老年人中淀粉样蛋白的相互作用和早期tau积聚的几个区域之间存在关联。然而，由于淀粉样蛋白升高的参与者数量较少，一些分析的效力不足，研究结果应谨慎解释。未来的研究将进一步横断面和纵向探索这些关联，以确定哈佛APT是否可以作为临床前AD预防试验和最终临床环境中可靠的IADL结果测量。
Detecting clinically meaningful changes in instrumental activities of daily living (IADL) at the earliest stages of Alzheimer’s disease (AD) is critical. The objective of this exploratory study was to examine the cross-sectional relationship between a performance-based IADL test, the Harvard Automated Phone Task (APT), and cerebral tau and amyloid burden in cognitively normal (CN) older adults. Seventy-seven CN participants underwent flortaucipir tau and Pittsburgh Compound B amyloid PET. IADL were assessed using the three Harvard APT tasks: prescription refill (APT-Script), health insurance company call (APT-PCP), and bank transaction (APT-Bank). Linear regression models were used to determine associations between each APT task and entorhinal cortex, inferior temporal, or precuneus tau with or without an interaction with amyloid. Significant associations were found between APT-Bank task rate and interaction between amyloid and entorhinal cortex tau, and APT-PCP task and interactions between amyloid and inferior temporal and precuneus tau. No significant associations were found between the APT tasks and tau or amyloid alone. Our preliminary findings suggest an association between a simulated real-life IADL test and interactions of amyloid and several regions of early tau accumulation in CN older adults. However, some analyses were underpowered due to the small number of participants with elevated amyloid, and findings should be interpreted with caution. Future studies will further explore these associations cross-sectionally and longitudinally in order to determine whether the Harvard APT can serve as a reliable IADL outcome measure for preclinical AD prevention trials and ultimately in the clinic setting.