DEVELOPMENT OF THE CONNECTIVE-TISSUE NETWORK IN THE NEONATAL HAMSTER HEART
DEVELOPMENT OF THE CONNECTIVE-TISSUE NETWORK IN THE NEONATAL HAMSTER HEART
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DOI：
10.1002/aja.1001650407
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发表时间：
1982-01-01
影响因子：
--
通讯作者：
BORG, TK
中科院分区：
文献类型：
--
作者：
BORG, TK
新生仓鼠心脏左心室结缔组织网络主要由胶原蛋白组成，主要在产后20天内形成。出生时没有的肌内膜的编织网络在产后4天可见，并且在产后15天与成人相似。随着心脏的生理性肥大，肌细胞-肌细胞和肌细胞-毛细血管支柱逐渐形成。这些数据与大鼠中结缔组织网络的发育相似，但仓鼠中的肌细胞-肌细胞支柱更多。据推测，这是因为仓鼠有更高的心率，这将需要更多的单核细胞的机械耦合。通过细胞外基质的胶原和非胶原成分的相互作用，支柱的形成似乎发生在肌膜上的精确区域。
The formation of the connective tissue network, composed principally of collagen, in the left ventricle of the neonatal hamster heart developed primarily during the first 20 days postpartum. The weave network of the endomysium, which was absent at birth, was visible by 4 days and was similar to that of the adult by 15 days postpartum. Myocyte-myocyte and myocyte-capillary struts formed gradually as the heart underwent physiological hypertrophy. These data were similar to the development of the connective tissue network in the rat except that the myocyte-myocyte struts were more numerous in the hamster. Presumably this is because the hamster has a higher heart rate, which would require more mechanical coupling of the monocytes. Formation of the struts appears to take place at precise areas on the sarcolemma through the interaction of collagenous and noncollagenous components of the extracellular matrix.