Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: a Review Featuring a Women's Health Perspective.
Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis: a Review Featuring a Women's Health Perspective.
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DOI：
10.14218/jcth.2014.00024
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发表时间：
2014-12
影响因子：
3.6
通讯作者：
Forouhar F
中科院分区：
文献类型：
--
作者：
Marchioni Beery RM;Vaziri H;Forouhar F
原发性胆汁性肝硬化（PBC）和原发性硬化性胆管炎（PSC）是两种主要类型的慢性胆汁淤积性肝病。每种疾病都有不同的特征和不同的进展，但最终都可能导致肝硬化和肝功能衰竭。以下提供了PBC和PSC的综述，从疾病病因、发病机制、诊断、临床特征、自然病程和治疗的一般概述开始。除了常见的相关表现疲劳，瘙痒症，脂溶性维生素缺乏症，选择与妇女的健康有关的疾病相关的主题进行了讨论，包括代谢性骨病，高脂血症和心血管疾病的风险，妊娠相关的问题，影响产妇的疾病过程和出生结果。这一对PBC和PSC的全面综述强调了女性胆汁淤积性肝病患者护理中的一些独特的临床考虑。
Primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) are two major types of chronic cholestatic liver disease. Each disorder has distinguishing features and variable progression, but both may ultimately result in cirrhosis and hepatic failure. The following offers a review of PBC and PSC, beginning with a general overview of disease etiology, pathogenesis, diagnosis, clinical features, natural course, and treatment. In addition to commonly associated manifestations of fatigue, pruritus, and fat-soluble vitamin deficiency, select disease-related topics pertaining to women's health are discussed including metabolic bone disease, hyperlipidemia and cardiovascular risk, and pregnancy-related issues influencing maternal disease course and birth outcomes. This comprehensive review of PBC and PSC highlights some unique clinical considerations in the care of female patients with cholestatic liver disease.