Airway epithelial cells: current concepts and challenges.
Airway epithelial cells: current concepts and challenges.
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DOI：
10.1513/pats.200805-041hr
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发表时间：
2008-09-15
期刊：
影响因子：
--
通讯作者：
Sunday, Mary E
中科院分区：
文献类型：
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作者：
Crystal, Ronald G;Randell, Scott H;Sunday, Mary E
成人支气管树覆盖有连续的上皮细胞层，其在维持空气管道中起关键作用，并且其是肺抵抗吸入的环境伴随物的防御的中心。上皮层与其他肺成分作为一个相互依赖的单位发挥作用。重要的是，气道上皮的结构和/或功能在主要的肺部疾病中紊乱，包括慢性阻塞性肺病、哮喘和支气管癌。在过去的几十年里，关于气道上皮的研究已经取得了许多进展，但是遗传学和干细胞/祖细胞生物学的新发展为理解气道上皮如何发育和维持以及它如何响应环境压力打开了大门。本文提供了一个关于气道上皮干/祖细胞，基因表达，细胞-细胞相互作用，和较低频率的细胞类型的知识现状的概述，并讨论了未来的挑战，调查领域的健康和疾病的气道上皮。
The adult human bronchial tree is covered with a continuous layer of epithelial cells that play a critical role in maintaining the conduit for air, and which are central to the defenses of the lung against inhaled environmental concomitants. The epithelial sheet functions as an interdependent unit with the other lung components. Importantly, the structure and/or function of airway epithelium is deranged in major lung disorders, including chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Investigations regarding the airway epithelium have led to many advances over the past few decades, but new developments in genetics and stem cell/progenitor cell biology have opened the door to understanding how the airway epithelium is developed and maintained, and how it responds to environmental stress. This article provides an overview of the current state of knowledge regarding airway epithelial stem/progenitor cells, gene expression, cell-cell interactions, and less frequent cell types, and discusses the challenges for future areas of investigation regarding the airway epithelium in health and disease.