Ghrelin induces adiposity in rodents
Ghrelin induces adiposity in rodents
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DOI：
10.1038/35038090
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发表时间：
2000-10-19
期刊：
影响因子：
64.8
通讯作者：
Heiman, ML
中科院分区：
文献类型：
--
作者：
Tschöp, M;Smiley, DL;Heiman, ML
胃饥饿素是一种肽类激素，是生长激素促分泌素（GHS）受体的内源性配体（1,2），其发现带来了一个令人惊讶的结果（3）：胃饥饿素合成的主要部位是胃，而非下丘脑。尽管胃饥饿素可能与生长激素释放激素和生长抑素一起调节垂体生长激素（GH）的分泌（3,4），但在下丘脑神经元（5）和脑干（6）中也发现了GHS受体。除了潜在的旁分泌作用外，胃饥饿素可能在胃、下丘脑和垂体之间建立一种内分泌联系，这表明它参与了能量平衡的调节。在此我们表明，在小鼠和大鼠中，每日外周给予胃饥饿素会通过减少脂肪利用而导致体重增加。脑室内给予胃饥饿素会使食物摄入量和体重呈剂量依赖性增加。大鼠血清胃饥饿素浓度在禁食时升高，在重新喂食或口服葡萄糖后降低，但饮水不会使其降低。我们提出，胃饥饿素除了在调节生长激素分泌方面的作用外，在需要提高代谢效率时会向下丘脑发出信号。
The discovery of the peptide hormone ghrelin, an endogenous ligand for the growth hormone secretagogue (GHS) receptor(1,2), yielded the surprising result(3) that the principal site of ghrelin synthesis is the stomach and not the hypothalamus. Although ghrelin is likely to regulate pituitary growth hormone (GH) secretion(3,4) along with GH-releasing hormone and somatostatin, GHS receptors have also been identified on hypothalamic neurons(5) and in the brainstem(6). Apart from potential paracrine effects, ghrelin may thus offer an endocrine link between stomach, hypothalamus and pituitary, suggesting an involvement in regulation of energy balance. Here we show that peripheral daily administration of ghrelin caused weight gain by reducing fat utilization in mice and rats. Intracerebroventricular administration of ghrelin generated a dose-dependent increase in food intake and body weight. Rat serum ghrelin concentrations were increased by fasting and were reduced by re-feeding or oral glucose administration, but not by water ingestion. We propose that ghrelin, in addition to its role in regulating GH secretion, signals the hypothalamus when an increase in metabolic efficiency is necessary.