Mouse Model for Efficacy Testing of Antituberculosis Agents via Intrapulmonary Delivery
Mouse Model for Efficacy Testing of Antituberculosis Agents via Intrapulmonary Delivery
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DOI：
10.1128/aac.00464-12
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发表时间：
2012-07-01
影响因子：
4.9
通讯作者：
Lenaerts, Anne J.
中科院分区：
文献类型：
--
作者：
Gonzalez-Juarrero, Mercedes;Woolhiser, Lisa K.;Lenaerts, Anne J.
Here we describe an experimental murine model that allows for aerosolized antituberculosis drug efficacy testing. Intrapulmonary aerosol delivery of isoniazid, capreomycin, and amikacin to mice with pulmonary infection of Mycobacterium tuberculosis demonstrated efficacy in reducing pulmonary bacterial loads similar to that seen by standard drug delivery methods, even when lower concentrations of drugs and fewer doses were used in the aerosolized drug regimens. Interestingly, intrapulmonary delivery of isoniazid also reduced the bacterial load in the spleen.
