Immune response modulation by curcumin in a latex allergy model.
Immune response modulation by curcumin in a latex allergy model.
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DOI：
10.1186/1476-7961-5-1
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发表时间：
2007-01-25
期刊：
影响因子：
--
通讯作者：
Fink, Jordan N
中科院分区：
文献类型：
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作者：
Kurup, Viswanath P;Barrios, Christy S;Raju, Raghavan;Johnson, Bryon D;Levy, Michael B;Fink, Jordan N
在过去的几十年里，过敏和哮喘在世界范围内增加，特别是在工业发达国家。这导致了新的兴趣，了解过敏的发病机制，在最近几年。过敏性疾病发病机制的进展导致了对新的替代疗法的探索，其中也包括草药。姜黄是亚洲常用的香料，姜黄中含有姜黄素，已被证明具有抗过敏和抗炎的潜力。我们使用乳胶过敏的小鼠模型来研究姜黄素作为免疫调节剂的作用。将BALB/c小鼠暴露于乳胶过敏原，并产生具有Th 2型免疫应答的乳胶过敏。这些动物用姜黄素治疗，并评估免疫和炎症反应。暴露于乳胶的动物显示血清IgE、乳胶特异性IgG 1、IL-4、IL-5、IL-13、嗜酸性粒细胞和肺部炎症增加。用姜黄素对乳胶致敏小鼠进行胃内治疗证明了Th 2应答减少，同时肺部炎症减少。姜黄素处理的小鼠中嗜酸性粒细胞显著减少，抗原呈递细胞上的共刺激分子表达（CD 80、CD 86和OX 40 L）减少，MMP-9、OAT和TSLP基因的表达也减弱。这些结果表明，姜黄素具有潜在的治疗价值，控制过敏反应所造成的暴露于过敏原。
There has been a worldwide increase in allergy and asthma over the last few decades, particularly in industrially developed nations. This resulted in a renewed interest to understand the pathogenesis of allergy in recent years. The progress made in the pathogenesis of allergic disease has led to the exploration of novel alternative therapies, which include herbal medicines as well. Curcumin, present in turmeric, a frequently used spice in Asia has been shown to have anti-allergic and inflammatory potential. We used a murine model of latex allergy to investigate the role of curcumin as an immunomodulator. BALB/c mice were exposed to latex allergens and developed latex allergy with a Th2 type of immune response. These animals were treated with curcumin and the immunological and inflammatory responses were evaluated. Animals exposed to latex showed enhanced serum IgE, latex specific IgG1, IL-4, IL-5, IL-13, eosinophils and inflammation in the lungs. Intragastric treatment of latex-sensitized mice with curcumin demonstrated a diminished Th2 response with a concurrent reduction in lung inflammation. Eosinophilia in curcumin-treated mice was markedly reduced, co-stimulatory molecule expression (CD80, CD86, and OX40L) on antigen-presenting cells was decreased, and expression of MMP-9, OAT, and TSLP genes was also attenuated. These results suggest that curcumin has potential therapeutic value for controlling allergic responses resulting from exposure to allergens.