Malignant cerebellar astrocytic tumours in children
Malignant cerebellar astrocytic tumours in children
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DOI：
10.1007/bf01407169
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发表时间：
2005
影响因子：
2.4
通讯作者：
Jun Shinoda;Hiromu Yamada;Noboru Sakai;T. Ando;T. Hirata;H. Hirayama
中科院分区：
文献类型：
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作者：
Jun Shinoda;Hiromu Yamada;Noboru Sakai;T. Ando;T. Hirata;H. Hirayama
作者回顾了5例经病理证实的儿童小脑恶性星形细胞瘤（2例间变性星形细胞瘤和3例胶质母细胞瘤）。所有病例均表现出颅内压升高和小脑病变的症状和体征。脑干症状4例。所有肿瘤均位于或接近小脑中线，无大囊肿。手术切除肿瘤（70 - 90%切除）4例。在一个病例中，仅进行了活检。即使随后的后续治疗，包括放疗，化疗，和/或免疫治疗，疾病的过程不能逆转，所有的孩子都死于入院后3至13个月（平均7个月），由于肿瘤再生长或复发。在2例病例中观察到肿瘤沿脑室系统壁沿着，认为这是此类肿瘤患者肿瘤复发的一种特殊、致命形式。儿童小脑恶性星形细胞肿瘤预后极差。除非有更好的治疗方法来抵消这一悲剧性后果，否则情况将继续如此。
The authors reviewed 5 cases of histopathologically verified malignant cerebellar astrocytic tumours (2 anaplastic astrocytomas and 3 glioblastomas) in children admitted to our department. All cases exhibited symptoms and signs of increased intracranial pressure and of a cerebellar lesion. Brain stem symptoms were present in 4 cases. All of the tumours were located in or near the midline of the cerebellum with no large cyst. Surgical removal (70 to 90% removal) of the tumour was performed in 4 cases. In one case only a biopsy was done. Even with subsequent follow-up treatment including radiotherapy, chemotherapy, and/or immunotherapy, the course of the disease could not be reversed, and all of the children died 3 to 13 months (mean 7 months) after admission due to tumour re-growth or recurrence. Tumour dissemination along the walls of the ventricular system was seen in 2 cases, and was considered to be a peculiar, fatal form of tumour recurrence in patients with this type of tumour. Malignant cerebellar astrocytic tumours in children have an extremely poor prognosis. Until, improved therapy is available to counteract this tragic consequence, it will remain so.