Somatostatin release from isolated perfused rat stomach.
Somatostatin release from isolated perfused rat stomach.
复制标题
生长抑素从离体灌注大鼠胃中释放。
DOI：
10.1016/0006-291x(78)90936-1
复制
发表时间：
1978
影响因子：
3.1
通讯作者：
H. Imura
中科院分区：
文献类型：
--
作者：
T. Chiba;Y. Seino;Y. Goto;S. Kadowaki;T. Taminato;H. Abe;Y. Kato;S. Matsukura;M. Nozawa;H. Imura
用灌流技术研究了大鼠离体胃的生长抑素释放。从灌流的大鼠胃中释放的生长抑素与合成的生长抑素在分子大小和免疫反应上是相同的。静脉注射胰高血糖素(10−7M)可引起胃内生长抑素释放的双相增加。灌流茶碱(10−3M)和二丁酰环腺苷(10−3M)也可刺激胃生长抑素的释放。这些结果提示腺苷环化酶-环磷酸腺苷系统可能参与了胃生长抑素释放的调节机制。
Gastric somatostatin release from the isolated rat stomach was studied using a perfusion technique. Somatostatin released from the isolated perfused rat stomach was found to be identical in molecular size and immunoreactively with synthetic somatostatin. Infusion of glucagon (10−7M) caused biphasic increase of gastric somatostatin release. Gastric somatostatin release was also stimulated by infusion of theophylline (10−3M) and dibutyryl cyclic AMP (10−3M). These results indicate the possible involvement of adenylate cyclase-cyclic AMP system in the regulatory mechanism of gastric somatostatin release.