Acute inflammatory syndrome induced by mycophenolate mofetil in a patient following kidney transplantation
Acute inflammatory syndrome induced by mycophenolate mofetil in a patient following kidney transplantation
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DOI：
10.1111/j.1600-6143.2006.01251.x
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发表时间：
2006-04-01
影响因子：
8.8
通讯作者：
Lhotta, K
中科院分区：
文献类型：
--
作者：
Hochegger, K;Gruber, J;Lhotta, K
霉酚酸酯（MMF）越来越多地用于预防肾移植和自身免疫性疾病后的急性和慢性排斥反应。在这里，我们报告了一例肾移植术后患者，在增加MMF剂量后1周内出现以发热和少关节炎为特征的急性炎症综合征。停用MMF后，该综合征在48小时内完全消失。我们在体外证明，当与MMF孵育时，患者的肉豆酸酯phbol acetate （PMA-）和甲酰基Met-Leu-Phe （fMLP-）刺激的多形核中性粒细胞（pmn）发生增加的氧化爆发。本报告表明MMF也可以诱导肾移植术后患者的急性炎症综合征，这种综合征可能是由于pmn的促炎反应。
Mycophenolate mofetil (MMF) is increasingly used to prevent acute and chronic rejection following kidney transplantation and in autoimmune diseases. Here, we report on a patient after kidney transplantation, who developed an acute inflammatory syndrome characterized by fever and oligoarthritis within 1 week after increasing the MMF dosage. MMF was discontinued resulting in a complete resolution of the syndrome within 48 h. We demonstrated in vitro that the patient's phorbol myristate acetate (PMA-) and formyl Met-Leu-Phe (fMLP-) stimulated polymorphonuclear neutrophils (PMNs) developed increased oxidative burst when incubated with MMF. This report demonstrates that MMF can also induce acute inflammatory syndrome in patients following kidney transplantation and that this syndrome might be due to a paradox, pro-inflammatory reaction of PMNs.