Effects of early life exposure to outdoor air pollution and indoor renovation on childhood asthma in China
Effects of early life exposure to outdoor air pollution and indoor renovation on childhood asthma in China
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早年暴露于室外空气污染和室内装修对中国儿童哮喘的影响
DOI：
10.1016/j.buildenv.2015.01.019
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发表时间：
2015-11-01
影响因子：
7.4
通讯作者：
Liu, Weiwei
中科院分区：
文献类型：
--
作者：
Deng, Qihong;Lu, Chan;Liu, Weiwei
近年来我国儿童哮喘的快速增加应该与暴露于高空气污染有关，但目前尚不清楚暴露于哪一个暴露窗口、暴露于哪种空气污染以及影响程度如何。我们调查了早期暴露于室外和室内空气污染对儿童哮喘的影响。对长沙市2490名3-6岁儿童进行问卷调查。根据三种室外空气污染物，即颗粒物（PM10），工业相关的SO2和交通相关的NO2，以及以新家具和重新装修为代表的两种室内空气污染，对每个儿童在子宫内和生命第一年的早期暴露进行了评估。多因素Logistic回归分析暴露对哮喘的影响。结果表明，暴露于工业和交通相关的空气污染物，（SO2和NO2）显著增加儿童哮喘，比值比= 1.07（95% CI：1.03-1.12）和1.16（1.00-135），第一年浓度增加10 μ g/m3时分别为1.09（1.04-1.15）和1.26（1.06-1.50）。妊娠期接触新家具和家庭装修显著增加儿童哮喘，比值比分别为234（1.16-4.74）和2.21（1.29-3.81）。室外和室内暴露的影响是相互独立的。我们的结论是，早期生活暴露于室外空气污染和室内装修有助于中国儿童哮喘的快速发展，前者出生后更强，而后者出生前更强。(C)2015爱思唯尔有限公司版权所有。
Recent rapid increase of childhood asthma in China should be associated with exposure to the high air pollution, but it is unclear to which exposure window, to which kind of air pollution, and to what extent the effect. We investigated the effect of early life exposure to both outdoor and indoor air pollution on childhood asthma. Questionnaire survey was administered to 2490 children aged 3-6 years in Changsha. Early life exposure of each child in utero and during the first year of life was evaluated based on three outdoor air pollutants, i.e. particulate matters (PM10), industry-related SO2 and traffic-related NO2, and two kinds of indoor air pollution represented by new furniture and redecoration. Multivariate logistic regression method was used to estimate the effect of exposure on asthma. Results indicated that exposure to both industry- and traffic-related air pollutants (SO2 and NO2) significantly increased childhood asthma with odds ratio = 1.07 (95% CI: 1.03-1.12) and 1.16 (1.00-135) in utero and 1.09 (1.04-1.15) and 1.26 (1.06-1.50) during the first year for 10 mu g/m(3) increase in concentration. Exposure to new furniture and home redecoration during pregnancy significantly increased childhood asthma with odds ratio 234 (1.16-4.74) and 2.21 (1.29-3.81) respectively. The effects of outdoor and indoor exposures were independent to each other. We conclude that early life exposures to both outdoor air pollution and indoor renovation contributes to the rapid development of childhood asthma in China, the former stronger after birth but the latter stronger before birth. (C) 2015 Elsevier Ltd. All rights reserved.