Weight gain and the menopause: a 5-year prospective study.
Weight gain and the menopause: a 5-year prospective study.
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DOI：
10.3109/13697139909038063
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发表时间：
1999-09-01
期刊：
影响因子：
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通讯作者：
Dudley, E C
中科院分区：
文献类型：
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作者：
Guthrie, J R;Dennerstein, L;Dudley, E C
目的：为了前瞻性地研究体重、皮褶测量、腰围和腰/臀比的变化与绝经状态、激素治疗使用和生活方式factors.METHOD的关系，本研究对年龄在46-57岁之间的澳大利亚出生的女性进行了为期5年的随访，基线时：106名绝经前、106名围绝经期和21名激素治疗使用者。5年内整个队列的平均（SD）体重增加为2.1（5.1）kg。基线年龄与体重变化呈负相关（回归系数=-0.4，SE 0.1，p < 0.05）。5年后，20名妇女仍处于绝经前，80名处于围绝经期，112名自然绝经，21名仍在接受激素治疗。除继续接受激素治疗的妇女外，所有组的体重变化均大于零（p < 0.05）。绝经前妇女和自然绝经妇女的体重增加没有显著差异。髂上皮褶厚度（p < 0.05）、腰围和腰臀比的增加发生在经历绝经过渡期的妇女中，而在持续接受激素治疗的妇女中则没有。体重变化和基线体重，运动，酒精摄入量或smoking.CONCLUSION：体重增加与绝经状态的变化无关，也与任何生活方式因素无关。在基线时年龄较大的女性比年轻成员增加的体重要少。髂上皮褶厚度、腰围和腰臀比在绝经过渡期均增加。在随访期间，连续激素治疗使用者的平均体重、髂上皮褶测量值或腰围测量值没有增加。
OBJECTIVE: To investigate prospectively changes in weight, skin-fold measurements, waist circumference and waist/hip ratio in relation to changes in menopausal status, hormone therapy use and life-style factors.METHOD: The study was a 5-year follow-up of volunteers from a population-based cohort of Australian-born women aged 46-57 years at baseline: 106 premenopausal, 106 perimenopausal and 21 hormone therapy users.RESULTS: Mean (SD) weight gain of the entire cohort over 5 years was 2.1 (5.1) kg. Baseline age was negatively associated with weight change (regression coefficient = -0.4, SE 0.1, p < 0.05). After 5 years, 20 women remained premenopausal, 80 were perimenopausal, 112 had become naturally postmenopausal and 21 remained on hormone therapy. Changes in weight were greater than zero (p < 0.05) in all groups except for the women who remained on hormone therapy. There was no significant difference in weight gain between women who remained premenopausal and those who had a natural menopause. Increases in suprailiac skin-fold measurements (p < 0.05) and in waist circumference and waist/hip ratio occurred in women who experienced the menopausal transition but not in those who took hormone therapy continuously. There was no association between weight change and baseline weight, exercise, alcohol intake or smoking.CONCLUSION: Weight gain was not related to change in menopausal status nor to any life-style factors measured. Women who were older at baseline gained less weight than the younger members. Suprailiac skin-fold measurements, waist circumference and waist/hip ratio all increased during the menopausal transition. Continuous hormone therapy users showed no gain in mean weight, suprailiac skin-fold measurements or waist measurements over the follow-up period.