Get round and stiff for mitosis
Get round and stiff for mitosis
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DOI：
10.2976/1.2895661
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发表时间：
2008-04-01
期刊：
影响因子：
--
通讯作者：
Bornens, Michel
中科院分区：
文献类型：
--
作者：
Thery, Manuel;Bornens, Michel
细胞变圆是细胞分裂的共同特征。细胞在有丝分裂过程中所采用的球形形状显然既不是简单的分离，也不是使细胞采用似乎是机械平衡的整体软化或硬化。这是一个高度复杂的机械转换，通过膜折叠和外周信号聚焦可以匹配纺锤体大小，以确保适当的细胞分裂。最近对所涉及的机制的新见解将促使科学界关注脂质双层膜和底层肌动蛋白细胞骨架之间存在的物理联系的调节，因为现在看来，这些将强烈影响一些关键的细胞事件，如细胞分裂的空间组织。
Cell rounding is a common feature of cell division. The spherical shape that cells adopt during mitosis is apparently neither a simple detachment nor a global softening or stiffening that allows cells to adopt what seems to be a mechanical equilibrium. It is a highly complex mechanical transformation by which membrane folding and peripheral signals focusing can match spindle size in order to ensure a proper cell division. Recent new insight into the mechanism involved will prompt the scientific community to focus on the regulation of the physical links that exist between the lipid bilayer membrane and the underlying actin cytoskeleton since it now appears that these will strongly influence some crucial cellular events such as the spatial organization of cell division.