Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism
Higher cardiorespiratory fitness attenuates the risk of atherosclerosis associated with ADRB3 Trp64Arg polymorphism
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较高的心肺健康可降低与 ADRB3 Trp64Arg 多态性相关的动脉粥样硬化风险
DOI：
10.1007/s00421-014-2862-5
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Miyachi M.
中科院分区：
文献类型：
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作者：
Iemitsu M;Fujie S;Murakami H;Sanada K;Kawano H;Gando Y;Kawakami R;Tanaka N;Miyachi M.
目的β3肾上腺素能受体（β3-adrenergicreceptor，ADRB 3）Trp 64 Arg基因多态性与体重增加、胰岛素抵抗和糖尿病等动脉粥样硬化危险因素相关。习惯性运动可带来更高的心肺适能，并导致动脉粥样硬化危险因素的改善。然而，心肺适能水平和ADRB 3 Trp 64 Arg多态性对心血管疾病风险的影响尚不清楚。877名日本男性和女性（18-75岁）进行横断面调查，以澄清ADRB 3 Trp 64 Arg多态性和心血管疾病的风险之间的关系的影响，心肺功能的健康进行了评估，颈总动脉内膜中层厚度（ccIMT）和血脂谱作为动脉粥样硬化的替代标志物。我们在增量式踏车运动试验中测量了峰值摄氧量（O2 peak）。受试者被分为高（高配）和低（低配）水平的心肺适能的基础上的中位数值O2 peakfor sex and decade. ResultsLevel of body fat，甘油三酯和血糖水平较低，高密度脂蛋白胆固醇水平和O2 peakare higher in High-Fit subjects than Low-Fit subjects.ADRB3Trp64Arg多态性没有显着影响ccIMT或血脂谱。在低适应性受试者中，Arg/Arg基因型个体的ccIMT高于Trp/Trp和Trp/Arg基因型个体（均P < 0.0001）;然而，ADRB 3多态性对高适应性受试者无影响。
Purposeβ3-Adrenergic receptor (ADRB3) Trp64Arg polymorphism is associated with atherogenic risk factors that include weight gain, insulin resistance, and diabetes. Habitual exercise brings higher cardiorespiratory fitness and results in the amelioration of atherosclerotic risk factors. However, the effects of cardiorespiratory fitness level andADRB3Trp64Arg polymorphism on the risk of cardiovascular disease remain unclear. A cross-sectional investigation of 877 Japanese men and women (18–75 years old) was performed to clarify the effects of cardiorespiratory fitness on the relationship betweenADRB3Trp64Arg polymorphism and risk of cardiovascular disease.MethodCommon carotid intima-media thickness (ccIMT) and blood lipid profiles were assessed as surrogate markers of atherosclerosis. We measured peak oxygen uptake (O2peak) during incremental cycle ergometer exercise testing. Subjects were divided into groups with high (High-Fit) and low (Low-Fit) levels of cardiorespiratory fitness based on the median value ofO2peakfor sex and decade.ResultsLevels of body fat, triglycerides, and plasma glucose were lower and high-density lipoprotein cholesterol levels andO2peakwere higher in High-Fit subjects than Low-Fit subjects.ADRB3Trp64Arg polymorphism did not significantly affect ccIMT or blood lipid profiles. In Low-Fit subjects, ccIMT was higher in individuals with the Arg/Arg genotype compared to the Trp/Trp and Trp/Arg genotypes (eachP< 0.0001); however,ADRB3polymorphism had no effect in High-Fit subjects.ConclusionHigher levels of cardiorespiratory fitness may attenuate the risk of atherosclerosis associated withADRB3Trp64Arg polymorphism.