THE HUMAN LAMININ RECEPTOR IS A MEMBER OF THE INTEGRIN FAMILY OF CELL-ADHESION RECEPTORS
THE HUMAN LAMININ RECEPTOR IS A MEMBER OF THE INTEGRIN FAMILY OF CELL-ADHESION RECEPTORS
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DOI：
10.1126/science.2970671
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发表时间：
1988-09-02
期刊：
影响因子：
56.9
通讯作者：
RUOSLAHTI, E
中科院分区：
文献类型：
--
作者：
GEHLSEN, KR;DILLNER, L;RUOSLAHTI, E
通过层粘连蛋白的亲和层析，从人胶质母细胞瘤细胞中分离出粘附基底膜蛋白层粘连蛋白的受体。该受体具有与其他细胞外基质蛋白如纤连蛋白和玻连蛋白的受体类似的异二聚体结构。将层粘连蛋白受体掺入脂质体膜中使得脂质体能够附着于层粘连蛋白包被的表面。受体脂质体也在一定程度上附着在纤连蛋白包被的表面上，但不附着在其他基质蛋白上。这些特性鉴定层粘连蛋白受体为细胞粘附受体的整联蛋白家族的成员。
A receptor for the adhesive basement membrane protein, laminin, was isolated from human glioblastoma cells by affinity chromatography on laminin. This receptor has a heterodimeric structure similar to that of receptors for other extracellular matrix proteins such as fibronectin and vitronectin. Incorporation of the laminin receptor into liposomal membranes makes it possible for liposomes to attach to surfaces coated with laminin. The receptor liposomes also attached to some extent to surfaces coated with fibronectin, but not with other matrix proteins. These properties identify the laminin receptor as a member of the integrin family of cell adhesion receptors.