Neuropsychological assessment as a predictor of weight loss in obese adolescents
Neuropsychological assessment as a predictor of weight loss in obese adolescents
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DOI：
10.1038/ijo.2013.198
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发表时间：
2014-04-01
影响因子：
4.9
通讯作者：
Darzi, A.
中科院分区：
文献类型：
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作者：
Kulendran, M.;Vlaev, I.;Darzi, A.
背景：众所周知，肥胖的人比正常体重的人更冲动。冲动性被认为是体重减轻的一个预测因子。设计：一项前后研究，旨在首次确定在持续2-8周的生活方式和体力活动干预计划中，冲动性是否随体重减轻而变化。53名肥胖青少年，体重指数（BMI）为33.75 +/- 7.9，参加了一个住宿营地，并在基线时与50名非肥胖青少年进行了比较。平均BMI为20.6 ± 2.3的肥胖青少年。测量：用CANTAB（剑桥认知，剑桥，英国）停止信号任务测量抑制控制。MATLAB（The Mathswork Inc.，结果：肥胖组青少年冲动性高于正常体重组。完成夏令营后，BMI从33.76 kgm（-2）显著降低至30.93 kgm-2。停止信号反应时间（SSRT）从225.38 +/- 94.22降至173.76 +/- 107.05 ms（n = 47，P = 0.0001）。训练营期间抑制性控制的降低预示着BMI降低最大的人（Wilks' Lambda = 0.9，F（1，50）= 4.85，P = 0.034）。在营地的周数（Wilks' Lambda = 0.83，F（1，50）= 9.826，P = 0.003）和青少年的年龄（Wilks' Lambda = 0.87，F（1，50）= 5.98，P = 0.02）与SSRT测量的抑制控制的减少显著相关。在营地停留时间越长，SSRT降低越大（B = 25.45，t = 2.02，P = 0.05）。年龄的增加对抑制控制的降低有显著的调节作用（B =-0.3，t =-0.034，P = 0.05）。时间折扣的金钱奖励也下降显着campaint.CONCLUSION：这项研究强调了潜在的识别那些谁是肥胖的使用一个易于测量的心理测试。此外，这是第一项报告冲动减少和幸福改善的研究，作为政府批准的肥胖青少年住宅营地的一部分。冲动与重量的变化的潜在机制进行了讨论。
BACKGROUND: Obese individuals are known to be more impulsive than their normal-weight counterparts. Impulsivity has been postulated to be a predictor of weight loss.DESIGN: A pre-post study was designed to determine for the first time whether impulsivity changed with weight loss during a lifestyle and physical activity intervention programme lasting 2-8 weeks.SUBJECTS: Fifty-three obese adolescents with a body mass index (BMI) of 33.75 +/- 7.9 attending a residential camp were tested and compared at baseline with 50 non-obese adolescents with a mean BMI of 20.6 +/- 2.3.MEASUREMENTS: Inhibitory control was measured with the CANTAB (Cambridge Cognition, Cambridge, UK) Stop Signal Task. MATLAB (The Mathswork Inc., Natick, MA, USA) was used to measure the temporal discounting constant.RESULTS: The obese group was more impulsive than the normal weight adolescents. BMI reduced significantly from 33.76 kgm(-2) to 30.93 kgm-2 after completing camp. The stop signal reaction time (SSRT) decreased from 225.38 +/- 94.22 to 173.76 +/- 107.05 ms (n = 47, P = 0.0001). A reduction in inhibitory control during camp was predictive of those who showed the greatest reduction in BMI (Wilks' Lambda = 0.9, F(1,50) = 4.85, P = 0.034). The number of weeks in camp (Wilks' Lambda = 0.83, F(1,50) = 9.826, P = 0.003) and the age of the adolescents (Wilks' Lambda = 0.87, F(1,50) = 5.98, P = 0.02) were significantly associated with a reduction in inhibitory control as measured by the SSRT. A longer stay in camp was associated with a greater reduction in SSRT (B = 25.45, t = 2.02, P = 0.05). Increasing age had a significant moderating role in the reduction of inhibitory control (B = -0.3, t = -0.034, P = 0.05). Temporal discounting for monetary reward also fell significantly during camp.CONCLUSION: This study highlights the potential to identify those who are obese by using an easy-to-measure psychometric test. Furthermore, it is the first study to report a reduction in impulsivity and an improvement in well-being as part of a government-approved residential camp for obese adolescents. The potential mechanisms for change in impulsivity with weight are discussed.