A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy
A beneficial effect of estrogen on working memory in postmenopausal women taking hormone replacement therapy
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DOI：
10.1006/hbeh.2000.1625
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发表时间：
2000-12-01
影响因子：
3.5
通讯作者：
Hampson, E
中科院分区：
文献类型：
--
作者：
Duff, SJ;Hampson, E
最近的神经生理学数据表明，前额叶皮质(PFC)可能对雌激素的调节敏感。在人类中，PFC调节了许多认知过程，这些过程有助于记忆功能，特别是工作记忆。这项研究调查了招募依赖PFC的信息处理的记忆任务是否可能在女性中表现出雌激素敏感性。评估了三组绝经后妇女在包括工作记忆测量在内的几项记忆任务中的表现：(1)仅服用雌激素的妇女(n=38，M-年龄=55.1岁)，(2)同时服用雌激素和孕激素的妇女(n=23，M-年龄=55.9岁)，(3)没有接受激素替代治疗的妇女(n=35，M-年龄=56.0岁)。雌激素使用者在言语任务和空间任务上表现出明显更好的表现，每个任务都有一个突出的工作记忆成分，但在涉及简单被动回忆的控制任务上，雌激素使用者与非雌激素使用者没有什么不同。这些发现与雌激素在PFC内活跃并能够影响依赖于该区域的功能的假设是一致的。这项研究的结果提出了雌激素可能在维持女性某些额叶功能方面发挥作用的可能性。(C)2000年学术出版社。
Recent neurophysiological data suggest that the prefrontal cortex (PFC) may be susceptible to modulation by estrogen. In humans, the PFC mediates a number of cognitive processes that contribute to memory function, particularly working memory. The present study examined whether memory tasks that recruit PFC-dependent information processing might exhibit estrogen sensitivity in women. Performance on several memory tasks, including measures of working memory, was evaluated in three groups of postmenopausal women: (1) women who were tested when taking estrogen only (n = 38, M-age = 55.1 years), (2) women who were tested when taking estrogen and a progestin concurrently (n = 23, M-age = 55.9 years), and (3) women who were not taking hormone replacement therapy (n = 35, M-age = 56.0 years). Estrogen users exhibited significantly better performance on a verbal task and on a spatial task, each with a prominent working memory component, but did not differ from nonusers on control tasks involving simple passive recall. These findings are consistent with the hypothesis that estrogen is active within PFC and is capable of influencing functions dependent on this region. The results of this study raise the possibility that estrogen may play a role in maintaining certain frontal lobe functions in women. (C) 2000 Academic Press.