Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism.
Cooperative Microbial Tolerance Behaviors in Host-Microbiota Mutualism.
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DOI：
10.1016/j.cell.2016.05.049
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发表时间：
2016-06-02
期刊：
影响因子：
64.5
通讯作者：
Ayres JS
中科院分区：
文献类型：
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作者：
Ayres JS
动物对微生物的防御策略通常被认为是免疫系统的功能，其主要功能是通过执行抗性机制来感知和杀死微生物。然而，这种对立的观点为我们理解有益的宿主-微生物相互作用带来了复杂性。病原微生物被描述为采用一些常见的行为，以牺牲宿主的健康和健身为代价来促进它们的健身。在这里，提出了一个补充框架，建议除了病原体，有益的微生物已经进化的行为来操纵主机的过程，以促进自己的健身，这样做，通过促进主机的健康和健身。在这个角度来看，我探讨的想法，传统上归因于病原微生物的模式或行为也被有益的微生物，以促进宿主耐受性防御策略。这种策略将促进宿主健康，而不会对微生物的适应性产生负面影响，从而产生合作的进化动力，这可能是驱动宿主和微生物互利共同进化所必需的。
Animal defense strategies against microbes are most often thought of as a function of the immune system, the primary function of which is to sense and kill microbes through the execution of resistance mechanisms. However, this antagonistic view creates complications for our understanding of beneficial host-microbe interactions. Pathogenic microbes are described as employing a few common behaviors that promote their fitness at the expense of host health and fitness. Here, a complementary framework is proposed to suggest that in addition to pathogens, beneficial microbes have evolved behaviors to manipulate host processes in order to promote their own fitness and do so through the promotion of host health and fitness. In this Perspective, I explore the idea that patterns or behaviors traditionally ascribed to pathogenic microbes are also employed by beneficial microbes to promote host tolerance defense strategies. Such strategies would promote host health without having a negative impact on microbial fitness and would thereby yield cooperative evolutionary dynamics that are likely required to drive mutualistic co-evolution of hosts and microbes.