Reactivity of Cortical Alpha Rhythms to Eye Opening in Mild Cognitive Impairment and Alzheimer's Disease: an EEG Study
Reactivity of Cortical Alpha Rhythms to Eye Opening in Mild Cognitive Impairment and Alzheimer's Disease: an EEG Study
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DOI：
10.3233/jad-2010-100798
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Rossini, Paolo M.
中科院分区：
文献类型：
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作者：
Babiloni, Claudio;Lizio, Roberta;Rossini, Paolo M.
静息闭眼α节律的皮质来源在轻度认知障碍（MCI）和阿尔茨海默病（AD）受试者中通常是异常的。在这里，我们测试的假设进行性损害皮层α反应性睁眼健忘症MCI和轻度AD受试者，反映了另一个方面的损害皮层神经同步。记录了36名正常老年人（Nold）、91名遗忘型MCI和31名轻度AD患者在闭眼和睁眼条件下的静息脑电图（EEG）数据。用LORETA软件估计脑电来源。在闭眼条件下，MCI和AD患者的后部α 1（8-10.5 Hz）源低于Nold受试者。对于枕叶δ源（2-4 Hz），情况正好相反。对睁眼条件的反应性显示，后α 1和α 2（10.5-13 Hz）源在Nold中较高，在MCI中居中，在AD受试者中较低。此外，MCI和AD受试者的枕叶α 1反应性与简易精神状态检查评分显示的认知障碍相关。总之，至少在组水平上，健忘性MCI和轻度AD状态之间的连续性与皮质神经元同步化对以α节律睁眼的反应性受损有关。
Cortical sources of resting eyes-closed alpha rhythms are typically abnormal in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects. Here we tested the hypothesis of a progressive impairment of cortical alpha reactivity to eye-opening across amnesic MCI and mild AD subjects, reflecting another aspect of the impairment of cortical neural synchronization. Resting electroencephalography (EEG) data were recorded in 36 normal elderly subjects (Nold), 91 amnesic MCI, and 31 mild AD subjects during eyes-closed and -open conditions. EEG sources were estimated by LORETA software. In the eye-closed condition, posterior alpha 1 (8-10.5 Hz) sources were lower in MCI and AD than Nold subjects. The opposite was true for occipital delta sources (2-4 Hz). Reactivity to the eyes-open condition showed posterior alpha 1 and alpha 2 (10.5-13 Hz) sources was high in the Nold, intermediate in the MCI, and low in the AD subjects. Furthermore, occipital alpha 1 reactivity across MCI and AD subjects was correlated to the cognitive impairment as revealed by Mini-Mental State Examination score. In conclusion, at least at group level, the continuum across amnesic MCI and mild AD status is related to an impaired reactivity of cortical neuronal synchronization to eyes opening at alpha rhythms.