Statistical evaluation and experimental design of a psoriasis xenograft transplantation model treated with cyclosporin A
Statistical evaluation and experimental design of a psoriasis xenograft transplantation model treated with cyclosporin A
复制标题
环孢素A治疗银屑病异种移植模型的统计评价和实验设计
作者：
K. Stenderup;C. Rosada;L. Alifrangis;Søren Andersen;T. N. Dam
摘要：将人皮肤移植到免疫缺陷小鼠身上的 银屑病异种移植模型在银屑病研究中被普遍接受。在过去的十年里，它们被广泛用于筛选具有潜在抗牛皮癣效果的新疗法。然而，实验设计在几个参数上有所不同。特别是，每个实验设计的供体和移植物的数量差异很大；这些数量直接与检测到统计上显著的药物效应的可能性有关。在这项研究中，我们对公认的抗银屑病药物环孢素A的疗效进行了统计评估，以生成一个统计模型，该模型可用于模拟不同实验设计的情景，并计算相关的统计研究能力，其定义为检测到具有统计学意义的抗银屑病药物治疗效果的概率。
Abstract: Psoriasis xenograft transplantation models where human skin is transplanted onto immune‐deficient mice are generally accepted in psoriasis research. Over the last decade, they have been widely employed to screen for new therapeutics with a potential anti‐psoriatic effect. However, experimental designs differ in several parameters. Especially, the number of donors and grafts per experimental design varies greatly; numbers that are directly related to the probability of detecting statistically significant drug effects. In this study, we performed a statistical evaluation of the effect of cyclosporine A, a recognized anti‐psoriatic drug, to generate a statistical model employable to simulate different scenarios of experimental designs and to calculate the associated statistical study power, defined as the probability of detecting a statistically significant anti‐psoriatic drug treatment effect.
影响因子：
15.9
作者：
WroneSmith, T;Nickoloff, BJ
通讯作者：
Nickoloff, BJ
严重联合免疫缺陷小鼠和人类银屑病皮肤嵌合体。
DOI：
--
发表时间：
1995
期刊：
The American journal of pathology.
影响因子：
--
作者：
Nickoloff,BJ;Kunkel,SL;Burdick,M;Strieter,RM
通讯作者：
Strieter,RM