EVIDENCE FOR DEVELOPMENTALLY PROGRAMMED TRANSDIFFERENTIATION IN MOUSE ESOPHAGEAL MUSCLE
EVIDENCE FOR DEVELOPMENTALLY PROGRAMMED TRANSDIFFERENTIATION IN MOUSE ESOPHAGEAL MUSCLE
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DOI：
10.1126/science.270.5243.1818
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发表时间：
1995-12-15
期刊：
影响因子：
56.9
通讯作者：
WAGNER, RA
中科院分区：
文献类型：
--
作者：
PATAPOUTIAN, A;WOLD, BJ;WAGNER, RA
转分化是一种相对罕见的现象，在这种现象中，一种分化的类型和功能的细胞切换到另一种离散的身份。在脊椎动物胚胎中，平滑肌和骨骼肌是不同的组织，它们来自中胚层的不同隔室。小鼠食道的肌肉系统在出生后的早期发育过程中被发现经历了从胎儿的平滑肌肉到骨骼肌的转换。从平滑肌到骨骼肌的转换以单个细胞表达混合表型的短暂出现为特征，这表明这种转换是程序性转分化的结果。
Transdifferentiation is a relatively rare phenomenon in which cells of one differentiated type and function switch to a second discrete identity. In vertebrate embryos, smooth muscle and skeletal muscle are distinct tissues that arise from separate compartments of the mesoderm. The musculature of the mouse esophagus was found to undergo a conversion from smooth muscle in the fetus to skeletal muscle during early postnatal development. The switch from smooth to skeletal muscle features the transitory appearance of individual cells expressing a mixed phenotype, which suggests that this conversion is a result of programmed transdifferentiation.