Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögren's syndrome.
Epitopic targets for autoantibodies in systemic lupus erythematosus and Sjögren's syndrome.
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系统性红斑狼疮和干燥综合征自身抗体的表位靶点。
DOI：
10.1097/00002281-198901030-00022
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发表时间：
1989
影响因子：
5.1
通讯作者：
Tan,EM
中科院分区：
文献类型：
--
作者：
Chan,EK;Tan,EM
具有独特核抗原特异性的血清自身抗体是系统性红斑狼疮(SLE)和干燥综合征的特征。随着分子生物学方法的引入，对这些核抗原的结构和细胞内功能的研究积累了越来越多的知识(Tan，Adı免疫1989年，4493-151)。这些自身抗体已被用于发现小RNA的新物种，并用于阐明基本的细胞功能，如前体信使RNA的剪接和加工。自身抗原在进化意义上是高度保守的。在可获得信息的情况下，自身抗原是参与普遍功能的大分子，如dna复制、转录或rna加工和翻译，这表明自身抗体可能针对保守的抗原分子的功能区(Tan等，临床免疫免疫病1988，47：121-141)。自身免疫性疾病发病机制中的一个重要问题是确定自身免疫反应的靶点(S)。在SLE和Sjögren综合征中，已经定义了自身抗体的几个细胞靶点。表1显示了目前对这些自身抗原的性质和自身抗体流行率的了解。小核糖核蛋白(SnRNP)和SS-A/SS-B等已知靶标继续被积极研究，同时新的靶标自身抗原正在被鉴定。例如，Karwan和Kindas-Mugge|1最近报道，抗Sm血清和鼠类单抗也识别酵母55kd核糖核酸酶H，它被证明是一种与酵母剪接相关的核糖核蛋白-Somal SnR14 RNA。结果还表明，该核糖核酸酶H蛋白与Sm的B/B‘蛋白具有免疫学上的相关性。这一发现很有意义，因为像核糖核酸酶H这样的活性在SnRNP中还没有描述，并可能为Sm抗原的功能提供新的见解。表1包括新描述的抗热休克蛋白HSP90的自身抗体(Minota等人，/Clin Invest 1988，81：106)和HSP70的73kd/pl 5.5成员[2]，它存在于相对较高比例的SLE患者中。表1还包括一些罕见的自身抗体，如
Serum autoantibodies with unique specificity for nuclear antigens are hallmarks of systemic lupus erythematosus (SLE) and Sjögren's syndrome. The introduction of methods in molecular biology into the study of these nuclear antigens has resulted in the accumulation of an increasing body of knowledge concerning their structures and intracellular functions (Tan, Adı Immunol 1989, 4493–151). These autoantibodies have been used in the discovery of new species of small RNAs and in the elucidation of basic cellular functions such as the splicing and processing of precursor messenger RNA. Autoantigens are highly conserved in an evolutionary sense. Where information is available, the autoantigens are macromolecules involved in universal functions such as DNA replication, transcription or RNA processing, and translation, suggesting that autoantibodies may be directed at functional regions of the conserved antigenic molecules (Tan et al., Clin Immunol Immunopathol 1988, 47: 121–141).An important issue in the pathogenesis of autoimmune disease is to define the target (s) of the autoimmune response. In SLE and Sjögren's syndrome, several cellular targets for autoantibodies have been defined. Table 1 shows the current knowledge of the nature of these autoantigens and the prevalence of autoantibodies. The well-known targets such as small nuclear ribonucleoprotein (snRNP) and SS-A/SS-B continue to be actively investigated while new target autoantigens are being characterized. For example, Karwan and Kindas-Mugge| 1| recently reported that anti-Sm sera and murine monoclonal antibody also recognized a yeast 55-kd ribonuclease H, which was shown to be a ribonucleoprotein associated with yeast spliceo-somal snR14 RNA. The results also showed that this ri-bonuclease H protein was immunologically related to the B/B'protein of Sm. This finding is of interest because an activity like ribonuclease H has not been described in snRNP and may give new insights into the function of Sm antigen. Table 1 includes the newly described autoantibodies to heat shock proteins hsp90 (Minota et al.,/Clin Invest 1988, 81: 106) and the 73 kd/pl 5.5 member of the hsp70 [2], which is present in a relatively high percentage of SLE patients. Table 1 also includes some of the rare autoantibodies such as