Modifiable Risk Factors Associated With Moyamoya Disease A Case-Control Study
Modifiable Risk Factors Associated With Moyamoya Disease A Case-Control Study
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与烟雾病相关的可改变危险因素病例对照研究
DOI：
10.1161/strokeaha.120.030027
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发表时间：
2020-08-01
期刊：
影响因子：
8.3
通讯作者：
Zhao, Jizong
中科院分区：
文献类型：
--
作者：
Ge, Peicong;Zhang, Qian;Zhao, Jizong
背景和目的：烟雾病(MMD)的病因尚不清楚。我们的目的是在一项前瞻性的病例对照研究中调查可改变的危险因素与MMD的关系。方法：评估连续招募的成年MMD患者和年龄匹配的健康对照个体的临床和实验室特征。结果：本前瞻性研究包括138例成人患者和138例健康对照。Logistic回归分析显示，体重指数增加(优势比[OR]，1.121[95%CI，1.018~1.234]；P=0.020)和同型半胱氨酸(OR，1.201[95%CI，1.081~1.334]；P=0.001)与MMD的风险增加有关。而白蛋白升高(OR，1.043[95%CI，1.004~1.082；P=0.028)和高密度脂蛋白胆固醇(OR，1.043[95%CI，1.004~1.082]；P=0.028)与MMD的风险降低相关。此外，同型半胱氨酸(OR，1.070[95%CI，1.010~1.134]；P=0.023)与单侧病变显著相关。相比之下，白蛋白和高密度脂蛋白胆固醇的增加与MMD的风险较低相关。此外，同型半胱氨酸的增加与单侧MMD的高患病率有关。对可改变的MMD危险因素应给予更多的关注，以帮助我们寻找其病因和新的治疗方案。
Background and Purpose: The cause of moyamoya disease (MMD) remains unknown. We aimed to investigate the association between modifiable risk factors and MMD in a prospective, case-control study.Methods: Clinical and laboratory characteristics were evaluated in consecutively recruited adult patients with MMD and age-matched healthy control individuals. The potential risk factors for MMD were estimated by logistic regression analysis.Results: Our prospective study included 138 adult patients and 138 healthy control subjects. Logistic regression analyses showed that increased body mass index (odds ratio [OR], 1.121 [95% CI, 1.018-1.234];P=0.020) and homocysteine (OR, 1.201 [95% CI, 1.081-1.334];P=0.001) were associated with higher risk of MMD. Whereas increased albumin (OR, 1.043 [95% CI, 1.004-1.082];P=0.028) and high-density lipoprotein cholesterol (OR, 1.043 [95% CI, 1.004-1.082];P=0.028) were correlated with a lower risk of MMD. Furthermore, homocysteine (OR, 1.070 [95% CI, 1.010-1.134];P=0.023) was significantly related to unilateral lesions.Conclusions: Increased body mass index and homocysteine were associated with a higher risk of MMD. In contrast, increased albumin and high-density lipoprotein cholesterol were correlated with a lower risk of MMD. Furthermore, increased homocysteine was related to a higher prevalence of unilateral MMD. More attention should be paid to the modifiable risk factors of MMD, as these might help us finding its cause and new therapeutic regimen.