MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
MAPK-Activated Protein Kinases (MKs): Novel Insights and Challenges.
复制标题
DOI：
10.3389/fcell.2015.00088
复制
发表时间：
2015
影响因子：
5.5
通讯作者：
Gaestel M
中科院分区：
文献类型：
--
作者：
Gaestel M
在mapk的下游，如经典/非典型erk和p38 mapk，而不是jnk，信号通常由蛋白激酶介导，这些蛋白激酶被mapk磷酸化并激活，因此被称为mapk活化蛋白激酶（MAPKAPKs）。最近，人们对MAPK/MAPKAPK异二聚体蛋白激酶信号复合物组装的特异性有了新的认识。此外，还描述了mk的新功能方面，并对已建立的功能提出了挑战。这篇简短的综述将总结最近的研究进展，包括mk中的线性基序（LM）、RSK的erk非依赖性激活、一些RSK抑制剂的RSK非依赖性作用以及MK5/PRAK在肿瘤抑制中的挑战作用。
Downstream of MAPKs, such as classical/atypical ERKs and p38 MAPKs, but not of JNKs, signaling is often mediated by protein kinases which are phosphorylated and activated by MAPKs and, therefore, designated MAPK-activated protein kinases (MAPKAPKs). Recently, novel insights into the specificity of the assembly of MAPK/MAPKAPK hetero-dimeric protein kinase signaling complexes have been gained. In addition, new functional aspects of MKs have been described and established functions have been challenged. This short review will summarize recent developments including the linear motif (LM) in MKs, the ERK-independent activation of RSK, the RSK-independent effects of some RSK-inhibitors and the challenged role of MK5/PRAK in tumor suppression.