MULTISENSORY CONVERGENCE AND INTEGRATION IN THE NEOSTRIATUM AND GLOBUS-PALLIDUS OF THE RAT
MULTISENSORY CONVERGENCE AND INTEGRATION IN THE NEOSTRIATUM AND GLOBUS-PALLIDUS OF THE RAT
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DOI：
10.1016/0006-8993(94)01427-j
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发表时间：
1995-03-13
期刊：
影响因子：
2.9
通讯作者：
DONG, WK
中科院分区：
文献类型：
--
作者：
CHUDLER, EH;SUGIYAMA, K;DONG, WK
本实验观察了尾壳核（CPu）、苍白球（GP）和杏仁外侧核（La）神经元对听觉和体感刺激的细胞外反应特性。在这些领域中，共有61个神经元单独响应体感刺激（unisensory），或体感和听觉刺激（multisensory）。较高的体感刺激率降低CPu神经元的反应幅度比GP神经元。在多感觉神经元，结合体感和听觉刺激相比，unisensory刺激导致三个特征性的反应模式：增强，抑郁症或互动。听觉和躯体感觉刺激诱发的峰值频率延迟的时间错位改变了大多数神经元的反应幅度。CPu和GP神经元的反应特性和解剖连接性表明，观察到的多感觉整合效应可用于促进对低强度刺激的运动反应。
The extracellular response properties of neurons in the caudate-putamen (CPu), globus pallidus (GP) and lateral amygdaloid nucleus (La) evoked by auditory and somatosensory stimuli were investigated. A total of 61 neurons in these areas responded either singly to somatosensory stimulation (unisensory), or to both somatosensory and auditory stimulation (multisensory). Higher rates of somatosensory stimulation reduced the response magnitude of CPu neurons more than that of GP neurons. In multisensory neurons, combined somatosensory and auditory stimulation compared to unisensory stimulation resulted in three characteristic response patterns: enhancement, depression or interaction. Temporal misalignment of the peak frequency latencies evoked by auditory and somatosensory stimulation altered the response magnitude in the majority of neurons. The response properties and anatomical connectivity of CPu and GP neurons suggest that the observed multisensory integrative effects may be used to facilitate motor responses to low intensity stimuli.