Emerging investigator series: use of behavioural endpoints in the regulation of chemicals
Emerging investigator series: use of behavioural endpoints in the regulation of chemicals
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DOI：
10.1039/c9em00463g
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发表时间：
2020-01-01
影响因子：
5.5
通讯作者：
Ford, Alex T.
中科院分区：
文献类型：
--
作者：
Agerstrand, Marlene;Arnold, Kathryn;Ford, Alex T.
对行为生态毒理学的兴趣正在增长，部分原因是记录行为方面的技术和计算进步，但也因为检测能力的提高，促进了对环境相关浓度影响的报告。经同行审查的文献目前载有研究报告，调查包括农药和药物在内的化学品对脊椎动物和无脊椎动物的迁移、扩散、攻击性、社会性、生殖、摄食和反捕食行为的影响。为了理解如何在监管决策中使用行为研究，我们：（1）评估了在欧盟化学品监管中使用行为终点的法律的障碍;（2）分析了在欧盟化学品监管中使用行为终点的已知案例;（3）提供了与群体水平效应相关的行为终点的示例。我们的结论是，唯一的法律的障碍，在欧盟化学品法规中使用的行为端点是一个端点是否被认为是相关的人口水平或没有。我们还得出结论，调查行为终点的生态毒性研究偶尔会在欧盟化学品法规中使用，并强调行为终点可能与人口水平有关。为了改善目前行为研究在监管决策中的应用，需要所有相关利益相关者做出贡献。我们有以下建议：（1）研究人员应进行强有力的、精心设计的和透明的研究，强调研究与化学品监管的相关性;（2）编辑和科学期刊应促进详细、可靠和明确报告的研究;（3）监管机构和化学工业需要接受与人口水平相关的新行为终点。
Interest in behavioural ecotoxicology is growing, partly due to technological and computational advances in recording behaviours but also because of improvements of detection capacity facilitating reporting effects at environmentally relevant concentrations. The peer-reviewed literature now contains studies investigating the effects of chemicals, including pesticides and pharmaceuticals, on migration, dispersal, aggression, sociability, reproduction, feeding and anti-predator behaviours in vertebrates and invertebrates. To understand how behavioural studies could be used in regulatory decision-making we: (1) assessed the legal obstacles to using behavioural endpoints in EU chemicals regulation; (2) analysed the known cases of use of behavioural endpoints in EU chemicals regulation; and (3) provided examples of behavioural endpoints of relevance for population level effects. We conclude that the only legal obstacle to the use of behavioural endpoints in EU chemicals regulation is whether an endpoint is considered to be relevant at the population level or not. We also conclude that ecotoxicity studies investigating behavioural endpoints are occasionally used in the EU chemicals regulation, and underscore that behavioural endpoints can be relevant at the population level. To improve the current use of behavioural studies in regulatory decision-making contribution from all relevant stakeholders is required. We have the following recommendations: (1) researchers should conduct robust, well-designed and transparent studies that emphasize the relevance of the study for regulation of chemicals; (2) editors and scientific journals should promote detailed, reliable and clearly reported studies; (3) regulatory agencies and the chemical industry need to embrace new behavioural endpoints of relevance at the population level.