Toxins of Bacillus anthracis
Toxins of Bacillus anthracis
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DOI：
10.1016/s0041-0101(01)00161-1
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发表时间：
2001-11-01
期刊：
影响因子：
2.8
通讯作者：
Mock, M
中科院分区：
文献类型：
--
作者：
Brossier, F;Mock, M
炭疽杆菌是一种革兰氏阳性细菌，是炭疽病的病原体。这种微生物是包囊原和产毒素的。它分泌两种由三种蛋白质组成的毒素：保护性抗原（PA）、致死因子（LF）和水肿因子（EF）。致死毒素（PA + LF）引起动物的亚单位死亡，水肿毒素（PA + EF）引起水肿。水肿和致死因子通过保护性抗原内化到真核靶细胞中。EF和LF分别具有钙调素依赖性腺苷酸环化酶和金属蛋白酶活性。本文将对这三种蛋白的结构与功能关系、调控机制及其在致病和免疫保护中的作用进行综述。(C)2001年由Elsevier Science Ltd.出版
Bacillus anthracis, a gram positive bacterium, is the causative agent of anthrax. This organism is capsulogen and toxinogenic. It secretes two toxins which are composed of three proteins: the protective antigen (PA), the lethal factor (LF) and the edema factor (EF). The lethal toxin (PA + LF) provokes a subit death in animals, the edema toxin (PA + EF) induces edema. The edema and the lethal factors are internalised into the eukaryotic target cells via the protective antigen. EF and LF exert a calmoduline dependent adenylate cyclase and a metalloprotease activity respectively. Progress in the structure-function relationship of these three proteins, their regulation mechanisms and their roles in pathogenesis and immunoprotection will be exposed. (C) 2001 Published by Elsevier Science Ltd.